肾上腺素在咖啡对循环系统影响中的作用。

The role of epinephrine in the circulatory effects of coffee.

作者信息

Smits P, Pieters G, Thien T

出版信息

Clin Pharmacol Ther. 1986 Oct;40(4):431-7. doi: 10.1038/clpt.1986.203.

DOI:10.1038/clpt.1986.203

Abstract

The circulatory response to coffee was studied in 10 normotensive, 10 bilaterally adrenalectomized, and 10 hypertensive subjects. In the normotensive group, drinking coffee exerted a rise in blood pressure (+5.1/+11.5 mm Hg), a fall in heart rate (-6.0 bpm), a rise in plasma epinephrine (+257.2%), and no change in plasma norepinephrine. The response to coffee in the hypertensive group was similar or even enhanced. In the patients who had undergone adrenalectomy, the coffee-induced rise of diastolic blood pressure was attenuated (+7.9 mm Hg; P less than 0.05), whereas plasma norepinephrine showed a fall (-20.8%) and plasma epinephrine remained undetectable throughout all tests. Additionally, a fall of plasma renin activity after coffee was observed in all three groups. We conclude that the pressor response to coffee is not purely a result of circulating epinephrine or to stimulation of the renin-angiotensin-aldosterone system. On the other hand, the coffee-induced increase of plasma epinephrine may increase the pressor response to coffee.

摘要

在10名血压正常者、10名双侧肾上腺切除者和10名高血压患者中研究了对咖啡的循环反应。在血压正常组中，饮用咖啡使血压升高（+5.1/+11.5毫米汞柱），心率下降（-6.0次/分钟），血浆肾上腺素升高（+257.2%），而血浆去甲肾上腺素无变化。高血压组对咖啡的反应相似甚至增强。在接受肾上腺切除术的患者中，咖啡引起的舒张压升高减弱（+7.9毫米汞柱；P<0.05），而血浆去甲肾上腺素下降（-20.8%），并且在所有测试中血浆肾上腺素均未检测到。此外，在所有三组中均观察到饮用咖啡后血浆肾素活性下降。我们得出结论，对咖啡的升压反应并非纯粹是循环肾上腺素或肾素-血管紧张素-醛固酮系统受刺激的结果。另一方面，咖啡引起的血浆肾上腺素增加可能会增强对咖啡的升压反应。