Henan Provincial People's Hospital, NO.7 Weiwu Road, Zhengzhou, 450003, China.
Henan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, China.
Mol Biol Rep. 2022 Sep;49(9):8895-8906. doi: 10.1007/s11033-022-07368-3. Epub 2022 Mar 20.
Epithelial-mesenchymal transition (EMT) plays an important role in migration and invasion of cancer cell and the development of tissue fibrosis diseases. N-methyladenosine (mA) is the most extensive type of RNA methylation and has aroused extensive interest in recent years. However, mA methylation seems to play different roles in different cancer cells and tissue fibrotic diseases. To determine the function of mA methylation in EMT, we summarized the molecular mechanism of EMT and recent progress in the regulation of EMT by mA methylation, suggesting that mA methylation targets EMT program by affecting the expression of transcription factors, EMT markers, long noncoding RNA and EMT-associated signaling pathways, which provides more possibilities for early diagnosis and treatment.
上皮-间充质转化（EMT）在癌细胞的迁移和侵袭以及组织纤维化疾病的发展中起着重要作用。N6-甲基腺苷（m6A）是 RNA 甲基化中最广泛的类型，近年来引起了广泛的关注。然而，m6A 甲基化在不同的癌细胞和组织纤维化疾病中似乎发挥着不同的作用。为了确定 m6A 甲基化在 EMT 中的功能，我们总结了 EMT 的分子机制以及 m6A 甲基化对 EMT 的调控的最新进展，表明 m6A 甲基化通过影响转录因子、EMT 标志物、长非编码 RNA 和 EMT 相关信号通路的表达来靶向 EMT 程序，这为早期诊断和治疗提供了更多的可能性。
