Maghfour Jalal, Olayinka Jadesola, Hamzavi Iltefat H, Mohammad Tasneem F
Department of Dermatology, Henry Ford Health System, Detroit, Michigan, USA.
Medical School, SUNY Downstate Health Sciences University, New York City, New York, USA.
Pigment Cell Melanoma Res. 2022 May;35(3):320-327. doi: 10.1111/pcmr.13038. Epub 2022 Mar 31.
Post-inflammatory hyperpigmentation (PIH) is one of the most common disorders of acquired hyperpigmentation. It often develops following cutaneous inflammation and is triggered by various stimuli, from inflammatory and autoimmune conditions to iatrogenic causes and mechanical injuries. While it is well established that an increase in melanin production and distribution within the epidermis and dermis is a hallmark feature of this condition, the exact mechanisms underlying PIH are not completely understood. This article aims to review the current evidence on the pathophysiology of PIH as the cellular and molecular mechanism of PIH represents a promising avenue for the development of novel, targeted therapies.
炎症后色素沉着（PIH）是获得性色素沉着最常见的病症之一。它通常在皮肤炎症后出现，由各种刺激引发，从炎症和自身免疫性疾病到医源性原因和机械损伤。虽然已经明确表皮和真皮内黑色素生成和分布增加是这种病症的标志性特征，但PIH的确切机制尚未完全了解。本文旨在综述目前关于PIH病理生理学的证据，因为PIH的细胞和分子机制是开发新型靶向治疗方法的一个有前景的途径。
