Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Curr Opin Pharmacol. 2022 Jun;64:102204. doi: 10.1016/j.coph.2022.102204. Epub 2022 Mar 17.
Due to its low invasiveness and controllability, chemogenetic approaches offer a highly attractive option to modulate neuronal activity in basic research and future clinical applications. Chemogenetics have revolutionized neuroscience research by facilitating manipulations of selective brain circuits. To date, however, the large majority of these studies have been conducted in rodent models, while the wide application of chemogenetics in nonhuman primates (NHPs) is yet to occur. Still, important progress has been achieved in the use of chemogenetics in NHP studies in the last few years. Here we review the studies that have been published using chemogenetics in NHPs and discuss the current limitations of the technique to its more widespread use in NHPs and possible ways to overcome them.
由于其微创性和可控性，化学遗传学方法为调节基础研究和未来临床应用中的神经元活动提供了极具吸引力的选择。化学遗传学通过促进选择性脑回路的操作，彻底改变了神经科学研究。然而，到目前为止，这些研究中的绝大多数都是在啮齿动物模型中进行的，而化学遗传学在非人类灵长类动物（NHPs）中的广泛应用尚未实现。尽管如此，在过去几年中，在使用化学遗传学进行 NHP 研究方面已经取得了重要进展。在这里，我们回顾了已发表的使用化学遗传学在 NHP 中进行的研究，并讨论了该技术在 NHP 中更广泛应用的当前限制及其可能的克服方法。
