Ophthalmology, University Campus Bio-Medico, Rome, Italy.
Ophthalmology, University Campus Bio-Medico, Rome, Italy.
Exp Eye Res. 2022 Jun;219:109035. doi: 10.1016/j.exer.2022.109035. Epub 2022 Mar 17.
Ageing has been defined as a specific individual plasticity and remodeling capacity to the environment' insults and stimuli. The precise physiology of aging is not entirely understood. Several theories have been proposed and included programmed cell death, genetic mutations, the epigenetic clock, wear-and-tear and free radicals. Ocular surface represents a complex morpho-functional unit composed of different tissues that strictly interact to preserve homeostasis and function. Ageing severely disrupts this system by means of inflammaging and immunosenescence, leading to ocular surface failure in older population.
衰老是指个体对环境损伤和刺激的特定可塑性和重塑能力。衰老的确切生理学机制尚未完全阐明。目前已经提出了几种理论，包括程序性细胞死亡、基因突变、表观遗传时钟、磨损和自由基。眼表面是一个由不同组织组成的复杂形态功能单位，这些组织严格相互作用以维持体内平衡和功能。衰老通过炎症和免疫衰老严重破坏了这个系统，导致老年人群的眼表面功能障碍。
