Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai 400019, India.
Tatyasaheb Kore College of Pharmacy, Warananagar, Tal- Panhala, District-Kolhapur 416113, India.
Int J Pharm. 2022 Apr 25;618:121681. doi: 10.1016/j.ijpharm.2022.121681. Epub 2022 Mar 17.
Nanotechnology has been a dynamic field for formulation scientists with multidisciplinary research being conducted worldwide. Advancements in development of functional nanosystems have led to evolution of breakthrough technologies. Lipidic nanosystems, in particular, are highly preferred owing to their non-immunogenic safety profiles along with a range of versatile intrinsic properties. Surface modification of lipid nanoparticles by anchoring carbohydrates to these systems is one such attractive drug delivery technology. Carbohydrates confer interesting properties to the nanosystems such as stealth, biostability, bioavailability, reduced toxicity due to decreased immunogenic response, targeting potential as well as ease of commercial availability. The carbohydrate anchored systems can be developed using methods such as adsorption, incorporation (nanoprecipitation or solvent displacement method), crosslinking and grafting. Current review provides a detailed overview of potential lipid based nanoparticulate systems with an emphasis on liposomes, solid lipid nanoparticles, nanostructures lipid carriers and micelles. Review further explores basics of surface modification, methods applied therein, advantages of carbohydrates as surface modifiers, their versatile applications, techniques for characterization of carbohydrate anchored systems and vital regulatory aspects concerned with these specialized systems.
纳米技术一直是制剂科学家的一个充满活力的领域，全球范围内正在进行多学科研究。功能性纳米系统的发展取得了突破，催生了突破性技术。特别是脂质纳米系统，由于其非免疫原性的安全性，以及一系列多功能的固有特性，受到了高度的青睐。通过将碳水化合物锚定到这些系统上对脂质纳米粒子进行表面修饰是一种有吸引力的药物传递技术。碳水化合物赋予纳米系统一些有趣的特性，如隐形、生物稳定性、生物利用度、由于免疫反应降低而降低毒性、靶向潜力以及易于商业化。可以使用吸附、掺入（纳米沉淀或溶剂置换法）、交联和接枝等方法来开发带有碳水化合物的锚定系统。本综述详细概述了潜在的基于脂质的纳米颗粒系统，重点介绍了脂质体、固体脂质纳米粒、纳米结构脂质载体和胶束。综述进一步探讨了表面修饰的基础、其中应用的方法、碳水化合物作为表面修饰剂的优势、它们的多功能应用、用于表征碳水化合物锚定系统的技术以及与这些特殊系统相关的重要监管方面。
