Shidhaye S S, Vaidya Reshma, Sutar Sagar, Patwardhan Arati, Kadam V J
Bharati Vidyapeeth's College of Pharmacy, Navi Mumbai, India.
Curr Drug Deliv. 2008 Oct;5(4):324-31. doi: 10.2174/156720108785915087.
The first generation of solid lipid carrier systems in nanometer range, Solid Lipid Nanoparticles (SLN), was introduced as an alternative to liposomes. SLN are aqueous colloidal dispersions, the matrix of which comprises of solid biodegradable lipids. SLN are manufactured by techniques like high pressure homogenization, solvent diffusion method etc. They exhibit major advantages such as modulated release, improved bioavailability, protection of chemically labile molecules like retinol, peptides from degradation, cost effective excipients, improved drug incorporation and wide application spectrum. However there are certain limitations associated with SLN, like limited drug loading capacity and drug expulsion during storage, which can be minimized by the next generation of solid lipids, Nanostructured lipid carriers (NLC). NLC are lipid particles with a controlled nanostructure that improves drug loading and firmly incorporates the drug during storage. Owing to their properties and advantages, SLN and NLC may find extensive application in topical drug delivery, oral and parenteral administration of cosmetic and pharmaceutical actives. Cosmeceuticals is emerging as the biggest application target of these carriers. Carrier systems like SLN and NLC were developed with a perspective to meet industrial needs like scale up, qualification and validation, simple technology, low cost etc. This paper reviews present status of SLN and NLC as carrier systems with special emphasis on their application in Cosmeceuticals; it also gives an overview about various manufacturing techniques of SLN and NLC.
第一代纳米级固体脂质载体系统——固体脂质纳米粒（SLN），作为脂质体的替代物被引入。SLN是水性胶体分散体，其基质由固体可生物降解脂质组成。SLN通过高压均质化、溶剂扩散法等技术制备。它们具有多种主要优点，如控释、提高生物利用度、保护视黄醇、肽等化学不稳定分子不被降解、赋形剂成本效益高、提高药物包封率以及应用范围广泛。然而，SLN存在一些局限性，如载药量有限以及储存期间药物排出，而新一代固体脂质——纳米结构脂质载体（NLC）可将这些局限性降至最低。NLC是具有可控纳米结构的脂质颗粒，可提高载药量并在储存期间牢固地包封药物。由于其特性和优点，SLN和NLC可能在局部给药、化妆品和药物活性成分的口服及肠胃外给药方面有广泛应用。药妆品正成为这些载体最大的应用目标。开发SLN和NLC等载体系统是为了满足扩大规模、鉴定与验证、技术简单、成本低等工业需求。本文综述了SLN和NLC作为载体系统的现状，特别强调了它们在药妆品中的应用；还概述了SLN和NLC的各种制备技术。
