Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.
Curr Opin Neurobiol. 2022 Apr;73:102525. doi: 10.1016/j.conb.2022.102525. Epub 2022 Mar 16.
As small ectotherms, whose temperature equilibrates almost instantly with that of their environment, free-living nematodes rely on their behavior for thermoregulation. Caenorhabditis elegans has been extensively used as a model to address the fundamental mechanisms involved in thermosensation and the production of temperature-dependent behaviors. Behavioral responses include avoidance of acute noxious heat or cold stimuli and thermotactic responses to innocuous temperatures to produce oriented navigation in spatial thermogradients. In order to produce these behaviors, C. elegans relies on its ability to detect thermal cues with exquisite sensitivity, orchestrate a set of specific behavioral responses and adapt these responses in specific contexts, including according to past sensory experience and current internal states. The present review focuses on recent advances in our understanding of the processes occurring at the molecular, cellular, and circuit levels that enable thermosensory information processing and plasticity.
作为小型变温动物，其体温几乎与环境温度瞬时平衡，自由生活的线虫依赖于其行为来进行体温调节。秀丽隐杆线虫已被广泛用作模型，以解决参与热感觉和产生温度依赖性行为的基本机制。行为反应包括避免急性有害的热或冷刺激，以及对无害温度的趋热性反应，从而在空间温度梯度中产生定向导航。为了产生这些行为，线虫依赖于其检测热线索的能力，这种能力具有极高的敏感性，协调一组特定的行为反应，并根据特定的上下文（包括根据过去的感官体验和当前的内部状态）来调整这些反应。本综述重点介绍了我们在理解使热感觉信息处理和可塑性成为可能的分子、细胞和电路水平上发生的过程方面的最新进展。
