United States Pharmacopeial Convention, Rockville, Maryland, USA.
Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, Alabama, USA.
Phytother Res. 2022 May;36(5):2061-2071. doi: 10.1002/ptr.7438. Epub 2022 Mar 20.
The dried flower and flower bud of Styphnolobium japonicum (L.) Schott (Japanese Sophora flower and Japanese Sophora flower bud, respectively) have long been used as herbal medicines in Asia. Today, they are marketed as dietary supplements in the United States for their anti-oxidative properties and as a source of flavonoids, including rutin and quercetin. This review focused on the safety of S. japonicum flower and flower bud as dietary supplement ingredients. No serious adverse events or toxicity were reported in the clinical or experimental animal studies we reviewed. Although some studies indicated that rutin or quercetin may have potential for drug interactions, none were identified for S. japonicum flower or flower bud. S. japonicum flower and flower bud are not known to have been associated with serious health risks when appropriately consumed in dietary supplements and have been admitted to the U.S. Pharmacopeial Convention monograph development process. However, pregnant and breastfeeding women should seek the advice of a healthcare professional because no data are available on their use by these special populations.
山豆根（苦参）的干花和花蕾在亚洲长期以来一直被用作草药。如今，它们在美国被作为膳食补充剂销售，具有抗氧化特性，也是类黄酮（包括芦丁和槲皮素）的来源。本综述重点关注山豆根花和花蕾作为膳食补充剂成分的安全性。我们审查的临床或实验动物研究中均未报告严重不良事件或毒性。尽管一些研究表明芦丁或槲皮素可能具有药物相互作用的潜力，但尚未发现与苦参花或花蕾有关。当在膳食补充剂中适当食用时，苦参花和花蕾不会带来严重的健康风险，并且已被纳入美国药典专论开发过程。然而，孕妇和哺乳期妇女应寻求医疗保健专业人员的建议，因为没有关于这些特殊人群使用苦参的数据。
