Huang Wen-Can, He Yongjun, Wang Wei, Mao Xiangzhao
College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.
Macromol Rapid Commun. 2022 May;43(9):e2200031. doi: 10.1002/marc.202200031. Epub 2022 Apr 1.
Here, a multifunctional film (MFF) as an alternative tissue adhesive in the form of an interpenetrating network consisting of self-crosslinked aldehyde-functionalized chitosan (AC) and crosslinked poly(acrylic acid) (PAA) further coordinated with Ag is reported. The MFF combines enhanced toughness and stretchability, which is attributed to the synergistic effects of the double-network design. Covalent crosslinking maintains the overall integrity of the MFF matrix, while noncovalent crosslinking dissipates energy under deformation. Upon contact, the MFF quickly dries the tissue surface followed by instant physical crosslinking to the tissue. Subsequent covalent crosslinking between the aldehyde groups of the MFF and the primary amine groups on the surface of the tissue further stabilizes the adhesion. Meanwhile, Ag provides strong antibacterial properties to the MFF. Notably, in vivo studies demonstrate that the MFF allows facile and tough attachment to the wet and dynamic surface of rabbit liver and presents superior hemostasis and sealing properties. Furthermore, the MFF can be safely degraded without causing abnormal defects in vivo. The outstanding physicochemical properties of the MFF can potentially be a good alternative to existing sutures or staples and has potential for use in clinical practice.
在此，报道了一种多功能薄膜（MFF），它是一种相互贯穿网络形式的替代组织粘合剂，由自交联醛功能化壳聚糖（AC）和交联聚丙烯酸（PAA）组成，并进一步与银配位。MFF兼具增强的韧性和拉伸性，这归因于双网络设计的协同效应。共价交联维持了MFF基质的整体完整性，而非共价交联在变形时耗散能量。接触后，MFF迅速干燥组织表面，随后立即与组织进行物理交联。MFF的醛基与组织表面的伯胺基团之间随后的共价交联进一步稳定了粘附。同时，银赋予MFF强大的抗菌性能。值得注意的是，体内研究表明，MFF能够轻松且牢固地附着在兔肝脏的湿润且动态的表面上，并具有卓越的止血和密封性能。此外，MFF可以在体内安全降解而不会引起异常缺陷。MFF出色的物理化学性质可能成为现有缝合线或吻合钉的良好替代品，并具有临床应用潜力。
