SLC35B4通过O-连接的N-乙酰葡糖胺糖基化作用稳定肝癌中的c-MYC蛋白。
SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC.
作者信息
Jiang Tao, Yang Jinghong, Yang Huohong, Chen Wancheng, Ji Kaiyuan, Xu Yang, Yu Lili
机构信息
School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Department of Cardiology, Cardiovascular Key Lab of Zhejiang Province, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
出版信息
Front Pharmacol. 2022 Mar 2;13:851089. doi: 10.3389/fphar.2022.851089. eCollection 2022.
UDP-GlcNAc is a sugar substrate necessary for the O-GlcNAcylation of proteins. SLC35B4 is one of the nucleotide sugar transporters that transport UDP-GlcNAc and UDP-xylose into the endoplasmic reticulum and Golgi apparatus for glycosylation. The roles of SLC35B4 in hepatocellular carcinoma (HCC) tumorigenesis remain unknown. We find that the expression levels of SLC35B4 are higher in HCC tissues than adjacent non-tumor tissues. SLC35B4 is important for the proliferation and tumorigenesis of HCC cells. Mechanistically, SLC35B4 is important for the O-GlcNAc modification of c-Myc and thus the stabilization of c-Myc, which is required for HCC tumorigenesis. Therefore, SLC35B4 is a promising therapeutic target for treating HCC.
UDP-葡萄糖胺（UDP-GlcNAc）是蛋白质O-连接N-乙酰葡糖胺化修饰所必需的糖底物。溶质载体家族35成员B4（SLC35B4）是核苷酸糖转运蛋白之一，可将UDP-葡萄糖胺和UDP-木糖转运至内质网和高尔基体进行糖基化修饰。SLC35B4在肝细胞癌（HCC）肿瘤发生中的作用尚不清楚。我们发现，HCC组织中SLC35B4的表达水平高于相邻的非肿瘤组织。SLC35B4对HCC细胞的增殖和肿瘤发生很重要。从机制上讲，SLC35B4对c-Myc的O-连接N-乙酰葡糖胺修饰很重要，从而对c-Myc的稳定性很重要，而这是HCC肿瘤发生所必需的。因此，SLC35B4是治疗HCC的一个有前景的治疗靶点。
Zotero 插件