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新引入的双固化树脂改性硅酸钙水泥的生物活性

bioactivity of newly introduced dual-cured resin-modified calcium silicate cement.

作者信息

Elbanna Ahmed, Atta Diaa, Sherief Dalia I

机构信息

Department of Biomaterials, Faculty of Dentistry, Ain-Shams University, Cairo, Egypt.

Department of Spectroscopy, Physics Division, National Research Centre, Cairo, Egypt.

出版信息

Dent Res J (Isfahan). 2022 Jan 28;19:1. doi: 10.4103/1735-3327.336686. eCollection 2022.

DOI:10.4103/1735-3327.336686
PMID:35308449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8927947/
Abstract

BACKGROUND

This study was designed to investigate the bioactivity of a new dual cured calcium silicate cement (TheraCal PT) compared to its light cured (TheraCal LC) and chemically set (Biodentine) counterparts.

MATERIALS AND METHODS

The study is an original research article. Prepared cements discs were immersed in deionized water. Ca+ release was evaluated using inductively coupled plasma-optical emission spectrometry while pH was assessed using a pH meter after 1, 14, and 28 days. Discs for surface characterization were immersed in phosphate-buffered saline (PBS) and were examined using an environmental scanning electron microscope with energy dispersive X-ray (ESEM/EDX), immediately after setting and at 1, 14, and 28 days intervals after that. Attenuated total reflectance (ATR)/Fourier transform infrared (FTIR) and Raman spectroscopy analyses were performed after setting and after 28 days storage in PBS. Statistical analysis was performed using the two-way repeated measure analysis of variance test followed by Bonferroni test for multiple comparisons ( < 0.05).

RESULTS

Biodentine exhibited the highest mean values for Ca+ release (792,639,278 ppm) and pH (10.99, 12.7, 11.54) at all time intervals. ESEM/EDX displayed a continuous layer of calcium phosphate formed by Biodentine and TheraCal LC while TheraCal PT developed scarce interrupted precipitates after immersion in PBS. ATR/FTIR and Raman spectroscopy for the formed precipitates confirmed the presence of phosphate and Ca (OH) in Biodentine, TheraCal LC and TheraCal PT.

CONCLUSION

TheraCal PT exhibited limited bioactivity which may limit its prognosis in clinical applications for vital pulp therapy. TheraCal LC is considered a potential bioactive calcium silicate cement despite its lower Ca+ release compared to Biodentine. Highest bioactivity was observed in Biodentine.

摘要

背景

本研究旨在调查一种新型双固化硅酸钙水门汀（TheraCal PT）与其光固化（TheraCal LC）和化学固化（Biodentine）同类产品相比的生物活性。

材料与方法

本研究为原创性研究文章。将制备好的水门汀圆盘浸入去离子水中。使用电感耦合等离子体发射光谱法评估钙释放量，同时在1天、14天和28天后使用pH计评估pH值。用于表面表征的圆盘浸入磷酸盐缓冲盐水（PBS）中，并在凝固后以及之后的1天、14天和28天间隔使用带能谱仪的环境扫描电子显微镜（ESEM/EDX）进行检查。在凝固后以及在PBS中储存28天后进行衰减全反射（ATR）/傅里叶变换红外（FTIR）和拉曼光谱分析。使用双向重复测量方差分析检验进行统计分析，随后进行Bonferroni检验以进行多重比较（<0.05）。

结果

在所有时间间隔内，Biodentine的钙释放量（792、639、278 ppm）和pH值（10.99、12.7、11.54）均值最高。ESEM/EDX显示Biodentine和TheraCal LC形成了连续的磷酸钙层，而TheraCal PT在浸入PBS后形成了稀少的间断沉淀物。对形成的沉淀物进行的ATR/FTIR和拉曼光谱分析证实了Biodentine、TheraCal LC和TheraCal PT中存在磷酸盐和氢氧化钙。

结论

TheraCal PT表现出有限的生物活性，这可能会限制其在牙髓病治疗临床应用中的预后。尽管TheraCal LC与Biodentine相比钙释放量较低，但它被认为是一种潜在的生物活性硅酸钙水门汀。在Biodentine中观察到最高的生物活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32aa/8927947/bd7dcca2fdff/DRJ-19-1-g009.jpg
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