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利用多流转换器从纵向医疗保健数据中识别阿片类药物使用障碍。

Identifying Opioid Use Disorder from Longitudinal Healthcare Data using a Multi-stream Transformer.

机构信息

Institute for Biomedical Informatics.

Department of Computer Science.

出版信息

AMIA Annu Symp Proc. 2022 Feb 21;2021:476-485. eCollection 2021.

PMID:35308960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8861731/
Abstract

Opioid Use Disorder (OUD) is a public health crisis costing the US billions of dollars annually in healthcare, lost workplace productivity, and crime. Analyzing longitudinal healthcare data is critical in addressing many real-world problems in healthcare. Leveraging the real-world longitudinal healthcare data, we propose a novel multi-stream transformer model called MUPOD for OUD identification. MUPOD is designed to simultaneously analyze multiple types of healthcare data streams, such as medications and diagnoses, by attending to segments within and across these data streams. Our model tested on the data from 392,492 patients with long-term back pain problems showed significantly better performance than the traditional models and recently developed deep learning models.

摘要

阿片类药物使用障碍(OUD)是一场公共健康危机,每年给美国造成数十亿美元的医疗护理、工作场所生产力损失和犯罪成本。分析纵向医疗保健数据对于解决医疗保健领域的许多实际问题至关重要。我们利用真实世界的纵向医疗保健数据,提出了一种名为 MUPOD 的新型多流转换器模型,用于 OUD 识别。MUPOD 旨在通过关注这些数据流内部和跨数据流的各个部分,同时分析多种类型的医疗保健数据流,如药物和诊断。我们在 392492 名长期背痛患者的数据上进行了测试,结果表明,该模型的性能明显优于传统模型和最近开发的深度学习模型。

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本文引用的文献

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Predicting opioid use disorder and associated risk factors in a Medicaid managed care population.预测医疗补助管理式医疗人群中的阿片类药物使用障碍及相关风险因素。
Am J Manag Care. 2021 Apr;27(4):148-154. doi: 10.37765/ajmc.2021.88617.
2
Development of a machine learning algorithm for early detection of opioid use disorder.开发一种用于早期检测阿片类药物使用障碍的机器学习算法。
Pharmacol Res Perspect. 2020 Dec;8(6):e00669. doi: 10.1002/prp2.669.
3
BEHRT: Transformer for Electronic Health Records.BEHRT:电子健康记录的转换器。
Sci Rep. 2020 Apr 28;10(1):7155. doi: 10.1038/s41598-020-62922-y.
4
Predicting substance use disorder using long-term attention deficit hyperactivity disorder medication records in Truven.利用Truven中的长期注意力缺陷多动障碍用药记录预测物质使用障碍。
Health Informatics J. 2020 Jun;26(2):787-802. doi: 10.1177/1460458219844075. Epub 2019 May 19.
5
Modeling Health Benefits and Harms of Public Policy Responses to the US Opioid Epidemic.模拟美国阿片类药物泛滥公共政策反应的健康效益和危害。
Am J Public Health. 2018 Oct;108(10):1394-1400. doi: 10.2105/AJPH.2018.304590. Epub 2018 Aug 23.
6
Reframing the Opioid Epidemic as a National Emergency.将阿片类药物流行重新界定为国家紧急情况。
JAMA. 2017 Oct 24;318(16):1539-1540. doi: 10.1001/jama.2017.13358.
7
Deep learning for healthcare: review, opportunities and challenges.深度学习在医疗保健领域的应用:综述、机遇与挑战。
Brief Bioinform. 2018 Nov 27;19(6):1236-1246. doi: 10.1093/bib/bbx044.
8
Doctor AI: Predicting Clinical Events via Recurrent Neural Networks.人工智能医生:通过循环神经网络预测临床事件
JMLR Workshop Conf Proc. 2016 Aug;56:301-318. Epub 2016 Dec 10.
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Treatment utilization among persons with opioid use disorder in the United States.美国阿片类药物使用障碍患者的治疗利用情况。
Drug Alcohol Depend. 2016 Dec 1;169:117-127. doi: 10.1016/j.drugalcdep.2016.10.015. Epub 2016 Oct 19.
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Big data analytics in healthcare: promise and potential.医疗保健中的大数据分析:前景与潜力。
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