Murtza Mohammed, Bangash Ayesha, Rehman Ajaz-Ur, Pervaiz Amjadali, Imran Adeena
General Psychiatry, South West Yorkshire Partnership NHS Foundation Trust, Halifax, UK.
Old Age Psychiatry, South West Yorkshire Partnership NHS Foundation Trust, Halifax, UK.
Gen Psychiatr. 2022 Feb 28;35(1):e100674. doi: 10.1136/gpsych-2021-100674. eCollection 2022.
Neurosyphilis can mimic many neurological and psychiatric disorders. Though several of its varied central nervous system manifestations can be measured clinically and by neuroimaging, they are non-specific. Thus, this mimicry and the relative rarity of the illness in the present era make the diagnosis elusive. However, neurosyphilis is readily treatable; therefore, it must be considered a diagnostic possibility in the routine workup of early-onset dementia. This case report is of a young man presenting with psychosis and cognitive impairment. His brain scan showed hippocampal atrophy, a finding not often seen in neurosyphilis but more common in Alzheimer's disease. Without awareness of the various causes of mesiotemporal atrophy, clinicians may erroneously diagnose cases such as this one as a neurodegenerative disorder.
神经梅毒可模仿多种神经和精神疾病。尽管其多种中枢神经系统表现中的一些可通过临床检查和神经影像学进行测量，但这些表现并无特异性。因此，这种模仿以及该疾病在当今时代相对罕见的情况使得诊断难以捉摸。然而，神经梅毒很容易治疗；因此，在早发性痴呆的常规检查中必须考虑到其诊断可能性。本病例报告的是一名出现精神病和认知障碍的年轻男性。他的脑部扫描显示海马萎缩，这一发现在神经梅毒中并不常见，但在阿尔茨海默病中更为常见。如果临床医生不了解内侧颞叶萎缩的各种病因，可能会错误地将此类病例诊断为神经退行性疾病。
