Liu Xindong, Wang Mengnan, Aftab Rukhma
Faculty of Science, Hong Kong Baptist University, Hong Kong, China.
College of Information and Computer, Taiyuan University of Technology, Taiyuan, China.
Front Bioeng Biotechnol. 2022 Mar 2;10:791424. doi: 10.3389/fbioe.2022.791424. eCollection 2022.
In order to more accurately and comprehensively characterize the changes and development rules of lesion characteristics in pulmonary medical images in different periods, the study was conducted to predict the evolution of pulmonary nodules in the longitudinal dimension of time, and a benign and malignant prediction model of pulmonary lesions in different periods was constructed under multiscale three-dimensional (3D) feature fusion. According to the sequence of computed tomography (CT) images of patients at different stages, 3D interpolation was conducted to generate 3D lung CT images. The 3D features of different size lesions in the lungs were extracted using 3D convolutional neural networks for fusion features. A time-modulated long short-term memory was constructed to predict the benign and malignant lesions by using the improved time-length memory method to learn the feature vectors of lung lesions with temporal and spatial characteristics in different periods. The experiment shows that the area under the curve of the proposed method is 92.71%, which is higher than that of the traditional method.
为了更准确、全面地表征肺部医学图像中病变特征在不同时期的变化及发展规律,本研究对肺结节在时间纵向维度上的演变进行预测,并在多尺度三维(3D)特征融合的基础上构建不同时期肺部病变的良恶性预测模型。根据患者不同阶段的计算机断层扫描(CT)图像序列,进行三维插值以生成三维肺部CT图像。利用三维卷积神经网络提取肺部不同大小病变的三维特征以进行融合特征。构建时间调制长短期记忆网络,通过改进的时间长度记忆方法学习不同时期具有时空特征的肺部病变特征向量,以预测良恶性病变。实验表明,所提方法的曲线下面积为92.71%,高于传统方法。