Yu Qi, Zhou Ji-Bo
Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China.
Int J Ophthalmol. 2022 Mar 18;15(3):510-514. doi: 10.18240/ijo.2022.03.21. eCollection 2022.
With the increasing prevalence in recent years, myopia has become an essential global health concern. In most instances, an increased axial length of the eye is the structural cause of nearsightedness. The scleral remodeling, primarily dependent on the scleral extracellular matrix (ECM) changes, is significantly linked to eye lengthening. Scleral remodeling plays a critical function in the incidence and progression of myopia. This mini-review will focus on recent research progress of scleral remodeling in the hope of providing new ideas for the prophylaxis and treatment of myopia.
近年来，随着近视患病率的不断上升，近视已成为一个至关重要的全球健康问题。在大多数情况下，眼轴长度增加是近视的结构原因。巩膜重塑主要依赖于巩膜细胞外基质（ECM）的变化，与眼轴延长密切相关。巩膜重塑在近视的发生和发展中起着关键作用。本综述将聚焦于巩膜重塑的最新研究进展，以期为近视的预防和治疗提供新思路。
