Guo Zhenpeng, Yang Chenchen, Zhang Qiang, Shi Xinling, Li Xiaona, Zhang Qun, Wang Jianming
Department of Epidemiology, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education Institutions in Jiangsu Province, School of Public Health, Nanjing Medical University, 101 Longmian Ave., Nanjing, 211166, China.
Department of Health Management, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
BMC Cardiovasc Disord. 2025 Jan 23;25(1):44. doi: 10.1186/s12872-025-04489-y.
The triglyceride-glucose (TyG) index, a novel health indicator, has been widely employed to assess insulin resistance (IR). However, its relationship with fine particulate matter (PM) exposure remains inadequately investigated.
This study endeavors to probe the association between PM and TyG within the population of eastern China and to determine whether there are disparities in this association among diverse subgroups.
We conducted an ecological study on a cohort comprising 39,011 individuals who had undergone at least two physical examinations between 2017 and 2019 at the First Affiliated Hospital of Nanjing Medical University, China. TyG levels concerning short-term PM exposure were examined using a generalized additive model.
In the overall population, at lags of 0-7 and 0-14 days in the single-pollutant model, it was observed that a 10 µg/m rise in PM corresponded to a 0.0021 elevation in TyG levels. In the multi-pollutant models, at 0-7 and 0-14 days lags, a comparable increase in PM resulted in an increase in TyG of 0.0073 and 0.0044, respectively. The association remained significant in the subgroup analyses.
PM exposure is related to the TyG index. Controlling air pollution might contribute to maintainin normal lipid metabolism function.
甘油三酯-葡萄糖（TyG）指数作为一种新型健康指标，已被广泛用于评估胰岛素抵抗（IR）。然而，其与细颗粒物（PM）暴露之间的关系仍未得到充分研究。
本研究旨在探讨中国东部人群中PM与TyG之间的关联，并确定不同亚组之间这种关联是否存在差异。
我们对一个队列进行了生态研究，该队列由39011名个体组成，他们于2017年至2019年期间在中国南京医科大学第一附属医院至少接受了两次体检。使用广义相加模型研究短期PM暴露与TyG水平之间的关系。
在总体人群中，在单污染物模型中滞后0-7天和0-14天时，观察到PM每升高10µg/m³，TyG水平相应升高0.0021。在多污染物模型中，滞后0-7天和0-14天时，PM的类似升高分别导致TyG升高0.0073和0.0044。该关联在亚组分析中仍然显著。
PM暴露与TyG指数相关。控制空气污染可能有助于维持正常的脂质代谢功能。
