Singh Ranveer, Choudhary Abhilasha, Ram Raja
M.L.B. Govt. College, Nokha (Bikaner) Rajasthan 334803, India.
SBRM Govt PG College, Nagaur(Rajasthan) 341001, India.
Mater Today Proc. 2022;62:5230-5234. doi: 10.1016/j.matpr.2022.03.133. Epub 2022 Mar 14.
As COVID-19 suppresses the immune system and those who have recovered from COVID-19 are at risk of developing mucormycosis or black fungus so there is a need to develop new antifungal strategies by the use of medicinal plants. Medicinal plants have always been a subject of interest for drug discovery, ethno-botany, traditional and indigenous medicines. One of the successful strategies for the investigation of new bioactive compounds from medicinal plants includes the screening of plant extract, fractions followed by the purification of the constituents and screening for biological activity. In the present study, the heartwood of desert plant was screened for antifungal activity by Agar-well diffusion method against . The result obtained shows that heartwood extract and their fractions serve as an effective agent against selected fungi and efficiency is dependent upon the nature of fraction and vary with respect to specific fungi. The extract and fractions shows a wide antifungal potential against . The findings suggest that the medicinal plant under investigation might be a reasonable solution for fungal infections especially against .
由于新冠病毒会抑制免疫系统，且新冠康复者有患毛霉菌病或黑真菌病的风险，因此有必要通过使用药用植物来开发新的抗真菌策略。药用植物一直是药物发现、民族植物学、传统和本土医学关注的对象。从药用植物中研究新生物活性化合物的成功策略之一包括筛选植物提取物、馏分，随后纯化成分并筛选生物活性。在本研究中，采用琼脂孔扩散法对沙漠植物的心材进行抗真菌活性筛选，以对抗[具体真菌名称缺失]。所得结果表明，心材提取物及其馏分可作为对抗所选真菌的有效药剂，其效果取决于馏分的性质，且因特定真菌而异。提取物和馏分对[具体真菌名称缺失]显示出广泛的抗真菌潜力。研究结果表明，所研究的药用植物可能是真菌感染尤其是对抗[具体真菌名称缺失]的合理解决方案。
