Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago. 1905 West Taylor Street, Chicago, IL 60612, United States.
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago. 1905 West Taylor Street, Chicago, IL 60612, United States; Department of Microbiology and Immunology, University of Illinois at Chicago. 835 South Wolcott Avenue, Chicago, IL 60612, United States.
Eur J Pharm Biopharm. 2022 Apr;173:150-159. doi: 10.1016/j.ejpb.2022.03.001. Epub 2022 Mar 21.
Acyclovir and similar nucleoside analogs form an essential frontline treatment for various herpesvirus infections of the eye. However, these drugs have low ocular retention when delivered topically and need to be administered several times every day. We have previously demonstrated that acyclovir loaded into activated carbon can be used to significantly decrease dosage frequency in a murine model of ocular infection. In this study, we demonstrate that other nucleoside analogs such as ganciclovir, penciclovir and famciclovir have excellent loading and release profile similar to acyclovir. Similarly we also demonstrate that nucleoside analog loaded carbons termed DECON are effective at very low concentrations in treating active viral infection of human corneal epithelial cells. In this study, using a variety of techniques to evaluate corneal dryness, nerve sensitivity, intraocular pressure, corneal thickness, and somatic inflammation, we report that DECON is well tolerated after administration three times daily over the course of four weeks.
阿昔洛韦和类似的核苷类似物是治疗各种眼部疱疹病毒感染的基本一线治疗药物。然而，这些药物经局部给药时眼内保留率低，需要每天多次给药。我们之前的研究表明，负载阿昔洛韦的活性炭可用于显著降低眼部感染的小鼠模型中的给药频率。在这项研究中，我们证明了其他核苷类似物，如更昔洛韦、喷昔洛韦和泛昔洛韦，具有与阿昔洛韦相似的出色负载和释放特性。同样，我们还证明了负载核苷类似物的碳称为 DECON，以非常低的浓度有效治疗人角膜上皮细胞的活性病毒感染。在这项研究中，我们使用多种技术评估角膜干燥、神经敏感性、眼内压、角膜厚度和躯体炎症，报告表明，在四周内每天给药三次的过程中，DECON 的耐受性良好。
