Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.
Vanderbilt Epidemiology PhD Program, Vanderbilt University School of Medicine, Nashville, TN.
Pediatr Infect Dis J. 2022 Apr 1;41(4):277-283. doi: 10.1097/INF.0000000000003423.
The most common clinical manifestation of adenovirus (AdV) infection is acute respiratory illness (ARI). Specific AdV species associated with ARI hospitalizations are not well defined in the Middle East.
A viral surveillance study was conducted among children <2 years hospitalized in Amman, Jordan, from March 2010 to March 2013. Nasal and throat respiratory specimens were obtained from enrolled children and tested for viruses using a real-time reverse-transcription quantitative polymerase chain reaction. AdV-positive specimens were typed by partial hexon gene sequencing. Demographic and clinical features were compared between AdV detected as single pathogen versus co-detected with other respiratory viruses, and between AdV-B and AdV-C species.
AdV was detected in 475/3168 (15%) children hospitalized with ARI; of these, 216 (45%) specimens were successfully typed with AdV-C as the most common species detected (140/216; 65%). Children with AdV-single detection (88/475; 19%) had a higher frequency of fever (71% vs. 56%; P=0.015), diarrhea (18% vs. 11%; p=0.048), and/or seizures/abnormal movements (14% vs. 5%; p=0.003). Children with AdV co-detected with other viruses more likely required oxygen support [adjusted odds ratio (aOR) 1.91 (95% CI: 1.08, 3.39), P = 0.027] than those with AdV-single detection. Children with AdV-C had higher odds of co-detections with other viruses compared with those with AdV-B [aOR 4.00 (95% CI: 1.91, 8.44), P < 0.001].
Clinical differences were identified between AdV-single and AdV co-detected with other viruses, and between AdV-B and AdV-C. Larger studies with AdV typing are needed to determine additional epidemiological and clinical differences between specific AdV species and types.
腺病毒（AdV）感染的最常见临床表现为急性呼吸道疾病（ARI）。中东地区尚未明确与 ARI 住院相关的特定 AdV 物种。
2010 年 3 月至 2013 年 3 月，在约旦安曼对<2 岁住院的儿童进行了一项病毒监测研究。从入组儿童中采集鼻和咽呼吸道标本，使用实时逆转录定量聚合酶链反应检测病毒。通过部分六邻体基因测序对 AdV 阳性标本进行分型。比较了 AdV 作为单一病原体检测与与其他呼吸道病毒共同检测、AdV-B 和 AdV-C 种间的人口统计学和临床特征。
在因 ARI 住院的 3168 名儿童中，检测到 AdV475 例（15%）；其中，216 例（45%）成功进行了分型，最常见的检测到的 AdV 物种为 AdV-C（140/216；65%）。AdV 单一检测（475 例中的 88 例；19%）的儿童发热频率更高（71% vs. 56%；P=0.015），腹泻（18% vs. 11%；p=0.048）和/或癫痫发作/异常运动（14% vs. 5%；p=0.003）。与 AdV 单一检测相比，AdV 与其他病毒共同检测的儿童更可能需要氧支持[调整优势比（aOR）1.91（95%CI：1.08，3.39），P=0.027]。与 AdV-B 相比，AdV-C 与其他病毒共同检测的儿童更有可能发生共同检测[aOR 4.00（95%CI：1.91，8.44），P<0.001]。
AdV 单一检测与 AdV 与其他病毒共同检测以及 AdV-B 与 AdV-C 之间存在临床差异。需要进行更大规模的 AdV 分型研究，以确定特定 AdV 物种和类型之间的其他流行病学和临床差异。
