加利福尼亚 A-G，来自 scriblitifolium 的叶的樟科 coumarins。
Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium.
机构信息
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
Research Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
出版信息
J Nat Med. 2022 Jun;76(3):645-653. doi: 10.1007/s11418-022-01613-6. Epub 2022 Mar 22.
Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A-E (1-5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A-F (1-6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain.
从梅叶冬青树皮的甲醇提取物中经生物活性导向分离得到五个新的吡喃香豆素，即 caloforines A-E（1-5）和两个新的香豆素，caloforines F 和 G（6 和 7）。通过 1D 和 2D NMR 光谱解析了它们的结构，并通过 CD 光谱和 DFT 计算相结合研究了它们的绝对构型。Caloforines A-F（1-6）对恶性疟原虫 3D7 株表现出中等的抗疟活性。
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