Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan.
Research Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
J Nat Med. 2024 Jun;78(3):768-773. doi: 10.1007/s11418-024-01795-1. Epub 2024 Apr 2.
A novel trimeric monoterpenoid indole alkaloid, vincarostine A (1) consisting of an aspidosperma-iboga-aspidosperma type skeleton, was isolated from the whole plant of Catharanthus roseus. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and CD spectrum. Vincarostine A (1) showed anti-malarial activity.
一种新型的三聚单萜吲哚生物碱，长春罗辛 A（1），由长春花-鹅掌柴-长春花型骨架组成，从长春花全植物中分离得到。根据 2D NMR 数据和 CD 光谱，阐明了包括绝对立体化学在内的结构。长春罗辛 A（1）具有抗疟活性。
