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口腔发现与肾移植儿童和青少年。

Oral findings in kidney transplant children and adolescents.

机构信息

DDS at the Special Care Dentistry Centre, School of Dentistry of the University of São Paulo, São Paulo (SP), Brazil.

DDS, School of Dentistry, Federal University of Sergipe, Lagarto, Brazil.

出版信息

Int J Paediatr Dent. 2022 Nov;32(6):894-902. doi: 10.1111/ipd.12965. Epub 2022 May 4.

Abstract

BACKGROUND

Children and adolescents undergoing kidney transplantation may present oral conditions after the procedure, but a few studies have recently described them.

AIM

To describe the oral conditions of post-renal transplant children and adolescents.

DESIGN

Two calibrated dentists examined all the participants by assessing caries experience, enamel defects, periodontal condition and soft tissue lesions.

RESULTS

A total of 120 participants were included in the study, in which 63 (52.5%) were male and 57 (47.5%) were female, with a mean age of 12.78 ± 3.9 years. Among the participants, 104 (86.7%) showed at least one oral change directly related to kidney disease. The most frequent oral findings were enamel defect (49/120; 40.8%) and drug-induced gingival overgrowth (DIGO) (20/120; 16.7%). Gingival bleeding was observed on probing in 115 (95.8%) participants, whereas 69 (57.5%) presented dental calculus and 51 (42.5%) had caries experience.

CONCLUSION

Gingival bleeding, enamel defects and DIGO were the most frequent oral findings in kidney transplant children and adolescents. The use of amlodipine and anticonvulsants was associated with DIGO, and there was a positive correlation between oral ulcers and use of everolimus.

摘要

背景

接受肾移植的儿童和青少年在手术后可能会出现口腔状况,但最近才有少数研究对此进行了描述。

目的

描述肾移植后儿童和青少年的口腔状况。

设计

两名经过校准的牙医通过评估龋齿经历、牙釉质缺陷、牙周状况和软组织病变来检查所有参与者。

结果

共有 120 名参与者纳入本研究,其中 63 名(52.5%)为男性,57 名(47.5%)为女性,平均年龄为 12.78±3.9 岁。在参与者中,有 104 名(86.7%)至少有一种与肾脏疾病直接相关的口腔变化。最常见的口腔发现是牙釉质缺陷(49/120;40.8%)和药物诱导的牙龈增生(DIGO)(20/120;16.7%)。115 名(95.8%)参与者的探诊时有牙龈出血,69 名(57.5%)有牙石,51 名(42.5%)有龋齿经历。

结论

肾移植儿童和青少年中最常见的口腔发现是牙龈出血、牙釉质缺陷和 DIGO。使用氨氯地平和抗惊厥药与 DIGO 相关,口腔溃疡的发生与使用依维莫司之间存在正相关关系。

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