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小豆蔻对代谢综合征的影响:叙述性综述。

The effect of (cardamom) on the metabolic syndrome: Narrative review.

作者信息

Yahyazadeh Roghayeh, Ghasemzadeh Rahbardar Mahboobeh, Razavi Bibi Marjan, Karimi Gholamreza, Hosseinzadeh Hossein

机构信息

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Iran J Basic Med Sci. 2021 Nov;24(11):1462-1469. doi: 10.22038/IJBMS.2021.54417.12228.

Abstract

Metabolic syndrome (MetS), as a health-threatening factor, consists of various symptoms including insulin resistance, high blood sugar, hypertension, dyslipidemia, inflammation, and abdominal obesity that raise the risk of diabetes mellitus and cardiovascular disease. Cardiovascular diseases are important causes of mortality among the world population. Recently, there has been a growing interest in using phytomedicine and natural compounds in the prevention and treatment of various diseases. The data was gathered by searching various standard electronic databases (Google Scholar, Scopus, Web of Science, and PubMed) for English articles with no time limitations. All , , and clinical studies were included. (cardamom) is a rich source of phenolic compounds, volatile oils, and fixed oils. Cardamom and its pharmacologically effective substances have shown broad-spectrum activities including antihypertensive, anti-oxidant, lipid-modifying, anti-inflammatory, anti-atherosclerotic, anti-thrombotic, hepatoprotective, hypocholesterolemic, anti-obesity, and antidiabetic effects. This review aims to highlight the therapeutic effects of cardamom on MetS and its components including diabetes, hyperlipidemia, obesity, and high blood pressure as well as the underlying mechanisms in the management of MetS. Finally, it can be stated that cardamom has beneficial effects on the treatment of MetS and its complications.

摘要

代谢综合征(MetS)作为一种威胁健康的因素,由多种症状组成,包括胰岛素抵抗、高血糖、高血压、血脂异常、炎症和腹部肥胖,这些都会增加患糖尿病和心血管疾病的风险。心血管疾病是全球人口死亡的重要原因。最近,人们越来越关注使用植物药和天然化合物来预防和治疗各种疾病。通过搜索各种标准电子数据库(谷歌学术、Scopus、科学网和PubMed)收集无时间限制的英文文章来获取数据。纳入了所有……和临床研究。小豆蔻是酚类化合物、挥发油和固定油的丰富来源。小豆蔻及其药理活性物质已显示出广泛的活性,包括抗高血压、抗氧化、脂质调节、抗炎、抗动脉粥样硬化、抗血栓形成、肝脏保护、降胆固醇、抗肥胖和抗糖尿病作用。本综述旨在强调小豆蔻对代谢综合征及其组成部分(包括糖尿病、高脂血症、肥胖和高血压)的治疗作用以及代谢综合征管理中的潜在机制。最后,可以说小豆蔻对代谢综合征及其并发症的治疗具有有益作用。

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