Esin R G, Safina D R, Khakimova A R, Esin O R
Kazan State Medical Academy, Kazan, Russia.
Kazan (Volga Region) Federal University, Kazan, Russia.
Neurosci Behav Physiol. 2022;52(2):196-201. doi: 10.1007/s11055-022-01223-5. Epub 2022 Mar 18.
This review addresses the current understanding of the role of autoimmune neuroinflammation in the pathogenesis of vascular, neurodegenerative, and other diseases of the nervous system. The mechanisms of responses of resident CNS cells (glial cells, astrocytes) and peripheral immune system cells are presented. The therapeutic potentials of phosphodiesterase inhibitors, which have antiaggregant properties and can suppress autoimmune inflammation, are discussed. The phosphodiesterase inhibitor dipyridamole is regarded as a potential drug for this purpose.
本综述阐述了目前对自身免疫性神经炎症在血管性、神经退行性及其他神经系统疾病发病机制中作用的理解。文中介绍了中枢神经系统常驻细胞（神经胶质细胞、星形胶质细胞）和外周免疫系统细胞的反应机制。讨论了具有抗聚集特性且能抑制自身免疫炎症的磷酸二酯酶抑制剂的治疗潜力。磷酸二酯酶抑制剂双嘧达莫被视为用于此目的的一种潜在药物。
