Yang Kangkang, Zhou Quanbo, Qiao Bingbing, Shao Bo, Hu Shengyun, Wang Guixian, Yuan Weitang, Sun Zhenqiang
Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
Mol Ther Nucleic Acids. 2022 Jan 19;27:983-997. doi: 10.1016/j.omtn.2022.01.009. eCollection 2022 Mar 8.
Exosomes are extracellular vesicles released by various cell types that perform various biological functions, mainly mediating communication between different cells, especially those active in cancer. Noncoding RNAs (ncRNAs), of which there are many types, were recently identified as enriched and stable in the exocrine region and play various roles in the occurrence and progression of cancer. Abnormal angiogenesis has been confirmed to be related to human cancer. An increasing number of studies have shown that exosome-derived ncRNAs play an important role in tumor angiogenesis. In this review, we briefly outline the characteristics of exosomes, ncRNAs, and tumor angiogenesis. Then, the mechanism of the impact of exosome-derived ncRNAs on tumor angiogenesis is analyzed from various angles. In addition, we focus on the regulatory role of exosome-derived ncRNAs in angiogenesis in different types of cancer. Furthermore, we emphasize the potential role of exosome-derived ncRNAs as biomarkers in cancer diagnosis and prognosis and therapeutic targets in the treatment of tumors.
外泌体是由多种细胞类型释放的细胞外囊泡，具有多种生物学功能，主要介导不同细胞之间的通讯，尤其是在癌症中活跃的细胞之间的通讯。非编码RNA（ncRNA）有多种类型，最近被发现在外泌体区域富集且稳定，并在癌症的发生和发展中发挥各种作用。异常血管生成已被证实与人类癌症有关。越来越多的研究表明，外泌体来源的ncRNA在肿瘤血管生成中起重要作用。在本综述中，我们简要概述了外泌体、ncRNA和肿瘤血管生成的特征。然后，从多个角度分析了外泌体来源的ncRNA对肿瘤血管生成的影响机制。此外，我们重点关注外泌体来源的ncRNA在不同类型癌症血管生成中的调节作用。此外，我们强调外泌体来源的ncRNA作为癌症诊断和预后生物标志物以及肿瘤治疗靶点的潜在作用。
