Alemi Forough, Sadeghsoltani Fatemeh, Fattah Khashayar, Hassanpour Parisa, Malakoti Faezeh, Kardeh Sina, Izadpanah Melika, de Campos Zuccari Debora Aparecida Pires, Yousefi Bahman, Majidinia Maryam
Department of Clinical Biochemistry and Laboratory Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Chem Biol Drug Des. 2023 Nov;102(5):1257-1275. doi: 10.1111/cbdd.14300. Epub 2023 Jul 26.
Noncoding RNAs (ncRNAs) are engaged in key cell biological and pathological events, and their expression alteration is connected to cancer progression both directly and indirectly. A huge number of studies have mentioned the significant role of ncRNAs in cancer prevention and therapy that make them an interesting subject for cancer therapy. However, there are several limitations, including delivery, uptake, and short half-life, in the application of ncRNAs in cancer treatment. Exosomes are introduced as promising options for the delivery of ncRNAs to the target cells. In this review, we will briefly discuss the application and barriers of ncRNAs. After that we will focus on exosome-based ncRNAs delivery and their advantages as well as the latest achievements in drugging ncRNAs with exosomes.
非编码RNA（ncRNAs）参与关键的细胞生物学和病理事件，其表达改变直接或间接地与癌症进展相关。大量研究提及ncRNAs在癌症预防和治疗中的重要作用，这使其成为癌症治疗的一个有趣课题。然而，ncRNAs在癌症治疗应用中存在一些局限性，包括递送、摄取和半衰期短等问题。外泌体被认为是将ncRNAs递送至靶细胞的有前景的选择。在本综述中，我们将简要讨论ncRNAs的应用和障碍。之后，我们将聚焦于基于外泌体的ncRNAs递送及其优势，以及外泌体介导的ncRNAs药物研发的最新成果。
