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膀胱憩室对膀胱出口梗阻病理生理学的影响：豚鼠实验研究

The Effects of Bladder Diverticulum on the Pathophysiology of Bladder Outlet Obstruction: An Experimental Study in Guinea Pigs.

作者信息

Karadag Aslihan, Celebi Suleyman, Gun Soysal Feryal, Yildiz Ozaydin Ipek, Keskin Erbug

机构信息

Department of Pediatric Surgery, Istanbul University Faculty of Medicine, Istanbul, Turkey.

Department of Pediatric Surgery, Division of Pediatric Urology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.

出版信息

Sisli Etfal Hastan Tip Bul. 2021 Dec 29;55(4):560-564. doi: 10.14744/SEMB.2020.45389. eCollection 2021.

DOI:10.14744/SEMB.2020.45389
PMID:35317366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8907698/
Abstract

OBJECTIVES

This study is the first to urodynamically and histopathologically evaluates the effects of bladder diverticulum (BD) secondary to bladder outlet obstruction (BOO).

METHODS

Guinea pigs (n=32) weighing 900-1,000 g were divided randomly into four groups: Sham, BD, BOO, and BD combined with BOO. All guinea pigs in the four groups underwent urodynamic evaluation preoperatively and at 1 month postoperatively. The bladders were removed and examined histopathologically.

RESULTS

The post-operative filling detrusor pressure was lower in the Sham group (7.1±1.6 cm HO) than in the BD (21.4±5.6 cm HO) and BD with BOO groups (23.6±9.3 cm HO) (p<0.05). There was no difference between the Sham and BOO (9.5±4.0) groups. Post-operative bladder compliance was better in the Sham group (2.3±0.8 ml/cm HO) than in the BD (0.9±0.22 ml/cm HO) and BD with BOO groups (0.6±0.3 ml/cm HO) (p<0.05). Involuntary detrusor contraction was not observed in the Sham or BOO groups, but was observed in 37.5% of subjects in the BD and BD with BOO groups. On histological examination, the bladder wall was thicker (3.75±0.68 mm) (p=0.601), and the connective tissue volume was significant increased (p=0.046), in the bladder muscularis mucosa in the BD groups compared to the BOO group.

CONCLUSION

Physiological and histopathological changes in the bladder with BD combined with BOO are more evident than with BOO alone.

摘要

目的

本研究首次对膀胱出口梗阻（BOO）继发膀胱憩室（BD）的影响进行尿动力学和组织病理学评估。

方法

将体重900 - 1000克的32只豚鼠随机分为四组：假手术组、BD组、BOO组和BD合并BOO组。四组所有豚鼠在术前和术后1个月均接受尿动力学评估。切除膀胱并进行组织病理学检查。

结果

假手术组术后充盈期逼尿肌压力（7.1±1.6 cm H₂O）低于BD组（21.4±5.6 cm H₂O）和BD合并BOO组（23.6±9.3 cm H₂O）（p<0.05）。假手术组和BOO组（9.5±4.0）之间无差异。假手术组术后膀胱顺应性（2.3±0.8 ml/cm H₂O）优于BD组（0.9±0.22 ml/cm H₂O）和BD合并BOO组（0.6±0.3 ml/cm H₂O）（p<0.05）。假手术组或BOO组未观察到逼尿肌不自主收缩，但BD组和BD合并BOO组37.5%的受试者观察到。组织学检查显示，与BOO组相比，BD组膀胱肌层黏膜的膀胱壁更厚（3.75±0.68 mm）（p = 0.6（此处原文可能有误，推测应为p<0.05之类有意义的比较）），结缔组织体积显著增加（p = 0.046）。

结论

BD合并BOO时膀胱的生理和组织病理学变化比单纯BOO更明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f4/8907698/980d27098b98/SEMB-55-560-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f4/8907698/91f0d98c3fc4/SEMB-55-560-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f4/8907698/97d95b9756ac/SEMB-55-560-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f4/8907698/980d27098b98/SEMB-55-560-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f4/8907698/91f0d98c3fc4/SEMB-55-560-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f4/8907698/97d95b9756ac/SEMB-55-560-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f4/8907698/980d27098b98/SEMB-55-560-g003.jpg

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