Akaltun Mazlum Serdar, Altindağ Özlem, Akyol Ahmet, Göktürk Hilal, Aydeni Ali, Gürsoy Savaş, Gür Ali
Gaziantep University, Faculty of Medicine, Department of Physical Medicine and Rehabilitaton, Gaziantep, Turkey.
Noro Psikiyatr Ars. 2020 Oct 11;59(1):44-47. doi: 10.29399/npa.25092. eCollection 2022.
Fibromyalgia syndrome (FMS) is a clinical condition characterised by chronic generalised body pain, fatigue and presence of tender points. In this study, we hypothesized that FMS could be a type of neuropathic pain and investigated the relationship between neuropathic pain and sleep disturbance and depression. We also investigated the association between these clinical conditions and disease severity.
Seventy-six patients who had FMS diagnosis according to 2010 ACR criteria were included in the study. Patients were evaluated by Fibromyalgia Impact Questionnaire (FIQ), Hamilton Depression Rating Scale (HAM-D), Pittsburgh Sleep Quality Index (PSQI), Douleur Neuropathique 4 Questions (DN4) and Leeds Assessment of Neuropathic Symptoms and Signs (LANSS).
Patients had neuropathic pain in 92.1% of patients with LANSS and 82.9% of patients with DN4. According to the Pittsburg Sleep Quality Scale, 90.8% of patients had poor sleep quality. According to HAM-D, 82.9% of the patients had depression. The mean FIQ values of the patients were calculated as 63.16±10.73. There was a positive correlation between DN4 values and FIQ, PSQI, HAM-D and LANSS. There was a positive correlation between LANSS values and FIQ and PSQI values.
In this study we found the frequency of neuropathic pain high in FMS. We also found a positive association between neuropathic pain scales and depression, sleep disturbance, and fibromyalgia impact score. Pain, functionality and psychosocial characteristics should be assessed extensively to understand fibromyalgia completely. Abnormal pain process and secondary clinical conditions should be considered together.
纤维肌痛综合征（FMS）是一种以慢性全身性疼痛、疲劳和存在压痛点为特征的临床病症。在本研究中，我们假设FMS可能是一种神经性疼痛，并研究了神经性疼痛与睡眠障碍和抑郁之间的关系。我们还研究了这些临床病症与疾病严重程度之间的关联。
本研究纳入了76例根据2010年美国风湿病学会（ACR）标准诊断为FMS的患者。通过纤维肌痛影响问卷（FIQ）、汉密尔顿抑郁评定量表（HAM-D）、匹兹堡睡眠质量指数（PSQI）、神经病理性疼痛4问题问卷（DN4）和利兹神经病理性症状和体征评估量表（LANSS）对患者进行评估。
根据LANSS，92.1%的患者存在神经性疼痛；根据DN4，82.9%的患者存在神经性疼痛。根据匹兹堡睡眠质量量表，90.8%的患者睡眠质量差。根据HAM-D，82.9%的患者存在抑郁。患者的平均FIQ值计算为63.16±10.73。DN4值与FIQ、PSQI、HAM-D和LANSS之间存在正相关。LANSS值与FIQ和PSQI值之间存在正相关。
在本研究中，我们发现FMS患者中神经性疼痛的发生率很高。我们还发现神经性疼痛量表与抑郁、睡眠障碍和纤维肌痛影响评分之间存在正相关。为了全面了解纤维肌痛，应广泛评估疼痛、功能和社会心理特征。应综合考虑异常疼痛过程和继发性临床病症。
