Lane R J, Turnbull D M, Welch J L, Walton J
Muscle Nerve. 1986 Sep;9(7):635-41. doi: 10.1002/mus.880090710.
Eleven patients, comprising three cases of McArdle's disease and eight with an exertional muscle pain syndrome (EMPS) of unknown cause, entered a double-blind crossover study of verapamil and placebo. None of the patients with McArdle's disease responded to verapamil, but two patients with unclassified EMPS experienced a striking improvement in symptoms and two others showed a partial response. No patient responded to placebo. Six of the eight cases with unclassified EMPS, including the four patients who responded to verapamil, had symptoms that indicated possible abnormalities of muscle metabolism, and four showed nonspecific biochemical, electromyographic, and muscle biopsy abnormalities. The two other EMPS patients had symptoms that suggested that a primary muscle disease was unlikely. They showed no laboratory evidence of muscle disorder, but had abnormal profiles on personality (MMPI) testing. Calcium antagonists, such as verapamil, may be useful in the treatment of some patients with benign exertional myalgia, but the mechanism of action of the drug in such cases is unclear.
11名患者（包括3例麦克尔迪氏病患者和8例病因不明的运动性肌肉疼痛综合征患者）参与了维拉帕米和安慰剂的双盲交叉研究。麦克尔迪氏病患者均对维拉帕米无反应，但2例未分类的运动性肌肉疼痛综合征患者症状显著改善，另外2例有部分反应。无患者对安慰剂有反应。8例未分类的运动性肌肉疼痛综合征患者中，有6例（包括对维拉帕米有反应的4例患者）有提示肌肉代谢可能异常的症状，4例有非特异性生化、肌电图和肌肉活检异常。另外2例运动性肌肉疼痛综合征患者的症状提示不太可能是原发性肌肉疾病。他们没有肌肉疾病的实验室证据，但在人格测试（明尼苏达多项人格调查表）中有异常表现。钙拮抗剂，如维拉帕米，可能对治疗某些良性运动性肌痛患者有用，但该药在此类病例中的作用机制尚不清楚。
