Camus G, Deby-Dupont G, Duchateau J, Deby C, Pincemail J, Lamy M
Laboratory of Human Applied Physiology, Université de Liège, Sart Tilman, Belgium.
Intensive Care Med. 1994 Nov;20(8):602-10. doi: 10.1007/BF01705731.
An increasing body of data suggest that strenuous exercise triggers an inflammatory response having some similarity with those occurring in sepsis. Indices of this inflammatory response to exercise (IRE) especially include leukocytosis, release of inflammatory mediators and acute phase reactants, tissue damage, priming of various white blood cell lines, production of free radicals; activation of complement, coagulation and fibrinolytic cascades. Inflammatory responses to strenuous exercise and sepsis could in part be due to the release of endotoxin in blood as common triggering factor, but it seems that tissue damage and/or contact system activation are more important triggering mechanisms in exercising subjects. While the magnitude and duration of cellular and humoral changes associated with IRE are quite different from those observed in sepsis, recent human studies suggested that chronic and/or excessive IRE could have adverse effects. Among the possible consequences of acute and chronic IRE are delayed onset muscular soreness and loss of force, cardiovascular complications, intravascular hemolysis, hypoferraemia and increased susceptibility to infection.
越来越多的数据表明，剧烈运动会引发一种炎症反应，这种反应与脓毒症时发生的炎症反应有一些相似之处。这种运动炎症反应（IRE）的指标特别包括白细胞增多、炎症介质和急性期反应物的释放、组织损伤、各种白细胞系的启动、自由基的产生；补体、凝血和纤溶级联反应的激活。对剧烈运动和脓毒症的炎症反应部分可能是由于血液中内毒素的释放作为常见触发因素，但似乎组织损伤和/或接触系统激活在运动受试者中是更重要的触发机制。虽然与IRE相关的细胞和体液变化的程度和持续时间与脓毒症中观察到的有很大不同，但最近的人体研究表明，慢性和/或过度的IRE可能会产生不良影响。急性和慢性IRE的可能后果包括延迟性肌肉酸痛和力量丧失、心血管并发症、血管内溶血、低铁血症和感染易感性增加。
