Salim R, van Gelderen de Komaid A
Mycopathologia. 1986 Jul;95(1):17-23. doi: 10.1007/BF00436317.
A possible correlation between pathogenesis and phagocytosis is established through comparison of the kinetics of the ingestion of nine Candida species by rat peritoneal macrophages in the early stages of infection. After 3 h of intraperitoneal injection of 6.10(8) yeasts to Sprague-Dawley rats, the phagocytic indices, candidacidal activity and the fate of the yeasts are assayed. Phagocytic indices allow separation of the species into four groups. Candidacidal activity and phagocytic indices are coincidently smaller in the more pathogenic species. Common events occur with the species assayed. All the yeasts can be isolated from blood, spleen and kidneys from the first h, whilst invasion to liver occurs from the second h post-infection.
通过比较大鼠腹腔巨噬细胞在感染早期对九种念珠菌的摄取动力学，建立了发病机制与吞噬作用之间的可能关联。向斯普拉格-道利大鼠腹腔注射6×10⁸个酵母3小时后，测定吞噬指数、杀念珠菌活性及酵母的转归。吞噬指数可将这些菌种分为四组。致病性较强的菌种，其杀念珠菌活性和吞噬指数同时较低。所检测的菌种出现一些共同情况。所有酵母在感染后第1小时即可从血液、脾脏和肾脏中分离出来，而对肝脏的侵袭则在感染后第2小时开始。
