氟原子修饰的 CuS-Au 杂化二聚体用于多模态成像引导的深部光热治疗。
Fluorine Grafted CuS-Au Heterodimers for Multimodal Imaging Guided Photothermal Therapy with High Penetration Depth.
机构信息
State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering , Beijing University of Chemical Technology , Beijing 100029 , China.
出版信息
J Am Chem Soc. 2018 May 9;140(18):5890-5894. doi: 10.1021/jacs.8b00368. Epub 2018 Apr 24.
We report the multifunctional nanocomposites (NCs) consisting of F-moieties grafted CuS-Au nanoparticles (NPs) for negligible background F-magnetic resonance imaging (F-MRI) and computed tomography (CT) imaging guided photothermal therapy. The localized surface plasmon resonance (LSPR) absorption can be reasonably tuned to the in vivo transparent window (800-900 nm) by coupling Au (<10 nm, LSPR ∼530 nm) with CuS (<15 nm, LSPR ∼1500 nm) into CuS-Au heterodimers. The in vivo photothermal tests show that CuS-Au show deeper light penetration with 808 nm irradiation, better photothermal efficacy, and less damage to normal tissues than CuS with 1500 nm irradiation. Moreover, compared to traditional H-MRI, the F-MRI based on these NCs demonstrates much better sensitivity due to the negligible background. This work offers a promising strategy for multimodal imaging guided photothermal therapy of deep tissue with good efficacy.
我们报告了多功能纳米复合材料（NCs），由接枝 F 基团的 CuS-Au 纳米粒子（NPs）组成，可用于可忽略的背景 F 磁共振成像（F-MRI）和计算机断层扫描（CT）成像引导的光热治疗。通过将 Au（<10nm，LSPR∼530nm）与 CuS（<15nm，LSPR∼1500nm）耦合到 CuS-Au 杂二聚体中，可以合理地将局域表面等离子体共振（LSPR）吸收调谐到体内透明窗口（800-900nm）。体内光热测试表明，与 CuS 用 1500nm 照射相比，CuS-Au 在 808nm 照射下具有更深的光穿透深度、更好的光热效果和对正常组织的更小损伤。此外，与传统 H-MRI 相比，基于这些 NCs 的 F-MRI 由于背景可忽略不计，因此具有更高的灵敏度。这项工作为具有良好疗效的深部组织的多模态成像引导光热治疗提供了一种有前途的策略。
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