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泛癌症分析揭示了 GTPBP 家族在癌症中的重要性。

Pan-cancer analysis revealed the significance of the GTPBP family in cancer.

机构信息

College of Pharmacy, Jiangsu Ocean University, Lianyungang, Jiangsu, China.

Department of General Surgery, Fuyang Hospital Affiliated to Anhui Medical University, Fuyang, Anhui, China.

出版信息

Aging (Albany NY). 2022 Mar 23;14(6):2558-2573. doi: 10.18632/aging.203952.

DOI:10.18632/aging.203952
PMID:35320117
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9004551/
Abstract

BACKGROUND

At present, cancer is still one of the principal diseases to represent a serious danger to human health. Although research on the pathogenesis and treatment of cancer is progressing rapidly, the current knowledge on this topic is far from sufficient. Some tumors with poor prognoses lack effective prognostic biomarkers.

METHODS

Firstly, the Wilcoxon test was used to analyse the expression of GTPBP1-GTPBP10 in cancerous and normal tissues. Subsequently, we explored the expression of GTPBP1-10 in cancer by way of a paired t-test and plotted the survival curve using KM and univariate Cox regression analysis to explore the relationship between GTPBP1-10 and the prognosis of cancer. We then explored the significance of the GTPBP family in the tumor microenvironment.

RESULTS

The results showed that many members of the GTPBP family are differentially expressed in a variety of cancers and alter the prognosis of a number of cancers. Members of the GTPBP family may serve as novel prognostic markers for these tumors. Moreover, members of the GTPBP family are correlated with the immune microenvironment of tumors, which is valuable in terms of adding to our understanding of the mechanisms of tumor genesis. Finally, we identified drugs showing a high correlation with GTPBP family members, which are therefore conducive to the development of GTPBP family member-based treatment regimens.

CONCLUSIONS

The 10 members of the GTPBP family have prognostic value in multiple tumor types and are associated with the immune microenvironment. Our study may provide a reference for the diagnosis and treatment of tumors.

摘要

背景

目前，癌症仍然是代表人类健康严重危害的主要疾病之一。虽然癌症的发病机制和治疗研究进展迅速，但目前对这一课题的认识还远远不够。一些预后不良的肿瘤缺乏有效的预后生物标志物。

方法

首先，采用 Wilcoxon 检验分析癌组织和正常组织中 GTPBP1-GTPBP10 的表达。然后，通过配对 t 检验探讨 GTPBP1-10 在癌症中的表达，通过 KM 和单因素 Cox 回归分析绘制生存曲线，探讨 GTPBP1-10 与癌症预后的关系。接着探讨 GTPBP 家族在肿瘤微环境中的意义。

结果

结果表明，GTPBP 家族的许多成员在多种癌症中差异表达，并改变了多种癌症的预后。GTPBP 家族成员可能成为这些肿瘤的新型预后标志物。此外，GTPBP 家族成员与肿瘤的免疫微环境相关，这对于增加对肿瘤发生机制的理解具有重要价值。最后，我们确定了与 GTPBP 家族成员具有高相关性的药物，这有利于制定基于 GTPBP 家族成员的治疗方案。

结论

GTPBP 家族的 10 个成员在多种肿瘤类型中具有预后价值，并与免疫微环境相关。我们的研究可能为肿瘤的诊断和治疗提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/9eb7fb6cb2d0/aging-14-203952-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/b5658b30e9b9/aging-14-203952-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/a7edb8e5f9ce/aging-14-203952-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/3d1de48e5951/aging-14-203952-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/dda9a4d1ea7c/aging-14-203952-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/6d66159948ed/aging-14-203952-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/5e412af76da4/aging-14-203952-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/1edd3a9c1994/aging-14-203952-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/9913634d6534/aging-14-203952-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/f47cef6c3c37/aging-14-203952-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/9eb7fb6cb2d0/aging-14-203952-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/b5658b30e9b9/aging-14-203952-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/a7edb8e5f9ce/aging-14-203952-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/3d1de48e5951/aging-14-203952-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/dda9a4d1ea7c/aging-14-203952-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/6d66159948ed/aging-14-203952-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/5e412af76da4/aging-14-203952-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/1edd3a9c1994/aging-14-203952-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/9913634d6534/aging-14-203952-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/f47cef6c3c37/aging-14-203952-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84da/9004551/9eb7fb6cb2d0/aging-14-203952-g010.jpg

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