Cao Yuan, Xie Jiaheng, Chen Liang, Hu Yiming, Zhai Leili, Yuan Jin, Suo Long, Shen Yaming, Ye Rong, Li Jiajun, Gong Zixuan, Dong Yunfan, Bao Wei, Li Huan, Wang Ming
The Fourth Clinical Medical College, Nanjing Medical University, Nanjing, China.
Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Cell Dev Biol. 2021 Nov 26;9:761350. doi: 10.3389/fcell.2021.761350. eCollection 2021.
Uveal melanoma is the most common primary intraocular tumor with a poor prognosis. Currently, treatment for UVM is limited, and the development of drug resistance and tumor recurrence are common. Therefore, it is important to identify new prognostic biomarkers of UVM and explore their role in the tumor microenvironment. Pyroptosis is a way of cell programmed death, and related research is in full throttle. However, the role of pyroptosis in UVM is unclear. In this study, we constructed the prognosis model of pyroptosis-related genes of UVM. This model can accurately guide the prognosis of UVM, and different groups differ in immune infiltration. We further verified our results in cell experiments. To some extent, our study can provide new ideas for the diagnosis and treatment of UVM.
葡萄膜黑色素瘤是最常见的原发性眼内肿瘤，预后较差。目前，葡萄膜黑色素瘤的治疗方法有限，耐药性的产生和肿瘤复发很常见。因此，识别葡萄膜黑色素瘤新的预后生物标志物并探索它们在肿瘤微环境中的作用很重要。细胞焦亡是一种细胞程序性死亡方式，相关研究正在全力推进。然而，细胞焦亡在葡萄膜黑色素瘤中的作用尚不清楚。在本研究中，我们构建了葡萄膜黑色素瘤细胞焦亡相关基因的预后模型。该模型可以准确指导葡萄膜黑色素瘤的预后，不同组在免疫浸润方面存在差异。我们在细胞实验中进一步验证了我们的结果。在某种程度上，我们的研究可以为葡萄膜黑色素瘤的诊断和治疗提供新的思路。
