Central Laboratory, Guangzhou Twelfth People's Hospital, Guangzhou, China.
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Neuroepidemiology. 2022;56(4):261-270. doi: 10.1159/000524208. Epub 2022 Mar 23.
Parkinson's disease is a common, age-related progressive neurodegenerative disorder with considerable socioeconomic burdens, although the studies in incremental burdens to the disease's rapid growth are incomplete and lag behind. We aim to assess global burdens of Parkinson's disease based on a public database online.
Based on the Global Burden of Disease, Injuries, and Risk Factors Study, we screened a range of indicators including prevalence cases, disability-adjusted life-years (DALYs), age-standardized prevalence rates (ASPRs), and age-standardized DALY rate (ASDR). The join point regression was used to assess the indicators, wherein the ASPR and the ASDR were referred to temporal trends for burdens of Parkinson's disease.
Prevalence cases of global Parkinson's disease were on the rise for 30 years, with an increase of 155.51% during 1990-2019. Temporal trend of ASDRs was on the rise during 1990-2002 but in decline during 2002-2019. The ASPRs had a turning point in 2017 and a decline during 2017-2019 (annual percentage change = -0.51%, p > 0.05). China, India, the USA, Japan, and Germany shared the five highest prevalence cases and DALYs in 2019. The Socio-Demographic Index (SDI) was in relation to a significantly positive ASPR (R = 0.61, p < 0.001) but not a significantly negative ASDR (R = -0.044, p = 0.53), respectively.
In this study, a range of indicators for global burdens of Parkinson's disease were on the rise during 1990-2019. Tremendous efforts should be in place to prevent Parkinson's disease, especially among the populations of males, with advanced ages, in East Asia, and in regions with high SDI.
帕金森病是一种常见的、与年龄相关的进行性神经退行性疾病，给社会经济带来了相当大的负担，尽管关于该病快速增长的增量负担的研究并不完整且滞后。我们旨在基于在线公共数据库评估全球帕金森病负担。
基于全球疾病、伤害和危险因素研究，我们筛选了一系列指标，包括患病率病例、残疾调整生命年（DALYs）、年龄标准化患病率（ASPRs）和年龄标准化 DALY 率（ASDR）。使用连接点回归评估指标，其中 ASPR 和 ASDR 用于评估帕金森病负担的时间趋势。
全球帕金森病患病率在 30 年内呈上升趋势，1990-2019 年间增加了 155.51%。1990-2002 年间 ASDRs 的趋势呈上升趋势，但 2002-2019 年间呈下降趋势。2017 年 ASPRs 出现拐点，2017-2019 年间呈下降趋势（年变化百分比=-0.51%，p>0.05）。2019 年，中国、印度、美国、日本和德国的帕金森病患病率病例和 DALYs 均居世界前五。社会人口指数（SDI）与显著的正 ASPR 相关（R=0.61，p<0.001），但与显著的负 ASDR 无关（R=-0.044，p=0.53）。
在这项研究中，1990-2019 年期间，全球帕金森病负担的一系列指标呈上升趋势。应大力预防帕金森病，特别是在男性、高龄、东亚和社会人口指数较高的人群中。
