新冠后持续存在的嗅觉功能障碍与味觉损害有关:急性感染八个月后化学感觉测试的结果
Persisting olfactory dysfunction in post-COVID-19 is associated with gustatory impairment: Results from chemosensitive testing eight months after the acute infection.
作者信息
Hintschich Constantin A, Fischer René, Hummel Thomas, Wenzel Jürgen J, Bohr Christopher, Vielsmeier Veronika
机构信息
Department of Otorhinolaryngology, Regensburg University Hospital, Regensburg, Germany.
Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
出版信息
PLoS One. 2022 Mar 23;17(3):e0265686. doi: 10.1371/journal.pone.0265686. eCollection 2022.
Olfactory and gustatory disorders are prominent symptoms of acute COVID-19. Although both senses recover in many patients within weeks to months, persistency has been described in up to 60%. However up to now most reports on the course of chemosensitive disorders after COVID-19 are not based on psychophysical testing but only on subjective patients' ratings. In this study we assessed both olfaction and gustation using psychophysical tests eight months after COVID-19. Validated psychophysical testing revealed hyposmia in 18% and hypogeusia in even 32% of 303 included patients. This shows that olfactory and especially gustatory disorders have to be seen as important chronic symptoms post-COVID-19. The high prevalence of gustatory dysfunction indicates that gustatory function does not recover or might even deteriorate in the months following the acute infection.
嗅觉和味觉障碍是新冠病毒急性感染的突出症状。尽管许多患者的这两种感觉在数周或数月内恢复,但仍有高达60%的患者症状持续存在。然而,到目前为止,大多数关于新冠病毒感染后化学感应障碍病程的报告并非基于心理物理学测试,而仅基于患者的主观评分。在本研究中,我们在新冠病毒感染八个月后使用心理物理学测试评估了嗅觉和味觉。经过验证的心理物理学测试显示,在纳入研究的303名患者中,18%存在嗅觉减退,甚至32%存在味觉减退。这表明嗅觉障碍,尤其是味觉障碍,必须被视为新冠病毒感染后的重要慢性症状。味觉功能障碍的高患病率表明,在急性感染后的几个月里,味觉功能没有恢复,甚至可能恶化。
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