Klein Hadar, Asseo Kim, Karni Noam, Benjamini Yuval, Nir-Paz Ran, Muszkat Mordechai, Israel Sarah, Niv Masha Y
Institute of Biochemistry, Food and Nutrition, Hebrew University, Rehovot, Israel.
Department of Medicine, Hadassah University Hospital, Mt Scopus Campus, Jerusalem, Israel; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Clin Microbiol Infect. 2021 Feb 16;27(5):769-74. doi: 10.1016/j.cmi.2021.02.008.
To characterize longitudinal symptoms of mild coronavirus disease 2019 (COVID-19) patients for a period of 6 months, to potentially aid in disease management.
Phone interviews were conducted with 103 patients with mild COVID-19 in Israel over a 6-month period (April 2020 to October 2020). Patients were recruited via social media and word to mouth and were interviewed up to 4 times, depending on reports of their unresolved symptoms. Inclusion criteria required participants to be residents of Israel aged 18 years or older, with positive COVID-19 real-time PCR results and nonsevere symptoms. The onset, duration, severity and resolution of symptoms were analysed.
A total of 44% (45/103), 41% (42/103), 39% (40/103) and 38% (39/103) of patients experienced headache, fever, muscle ache and dry cough as the first symptom respectively. Smell and taste changes were experienced at 3.9 ± 5.4 and 4.6 ± 5.7 days (mean ± standard deviation (SD)) after disease onset respectively. Among prevalent symptoms, fever had the shortest duration (5.8 ± 8.6 days), and taste and smell changes were the longest-lasting symptoms (17.2 ± 17.6 and 18.9 ± 19.7 days; durations censored at 60 days). Longer recovery of the sense of smell correlated with the extent of smell change. At the 6-month follow-up, 46% (47/103) of the patients had at least one unresolved symptom, most commonly fatigue (22%, 23/103), smell and taste changes (15%, 15/103 and 8%, 8/103 respectively) and breathing difficulties (8%, 8/103).
Long-lasting effects of mild COVID-19 manifested in almost half of the participants reporting at least one unresolved symptom after 6 months.
对轻度2019冠状病毒病（COVID-19）患者6个月期间的纵向症状进行特征描述，以辅助疾病管理。
在6个月期间（2020年4月至2020年10月），对以色列103例轻度COVID-19患者进行电话访谈。患者通过社交媒体和口口相传招募，根据其未缓解症状的报告，接受多达4次访谈。纳入标准要求参与者为18岁及以上的以色列居民，COVID-19实时聚合酶链反应结果呈阳性且症状不严重。对症状的发作、持续时间、严重程度和缓解情况进行分析。
分别有44%（45/103）、41%（42/103）、39%（40/103）和38%（39/103）的患者最初症状为头痛、发热、肌肉疼痛和干咳。疾病发作后分别在3.9±5.4天和4.6±5.7天（平均值±标准差（SD））出现嗅觉和味觉改变。在常见症状中，发热持续时间最短（5.8±8.6天），而味觉和嗅觉改变是持续时间最长的症状（17.2±17.6天和18.9±19.7天；持续时间以60天为 censored）。嗅觉恢复时间较长与嗅觉改变程度相关。在6个月随访时，46%（47/103）的患者至少有一项未缓解症状，最常见的是疲劳（22%，23/103）、嗅觉和味觉改变（分别为15%，15/103和8%，8/103）以及呼吸困难（8%，8/103）。
轻度COVID-19的长期影响在6个月后几乎一半报告至少有一项未缓解症状的参与者中显现。
