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心脏磁共振成像在浸润性、肥厚性和致心律失常性心肌病诊断中的作用

Role of Cardiac Magnetic Resonance in the Diagnosis of Infiltrative, Hypertrophic, and Arrhythmogenic Cardiomyopathies.

作者信息

Almeida Pedro Carvalho, Lopes Vanessa, Ferreira Luís Amaral, Moreira Nádia, Marto Carlos Miguel, Gonçalves Lino, Donato Paulo

机构信息

Medical Imaging Department, Coimbra Hospital and University Center, 3000-075 Coimbra, Portugal.

Cardiology Department, Coimbra Hospital and University Center, 3000-075 Coimbra, Portugal.

出版信息

Front Biosci (Schol Ed). 2022 Mar 8;14(1):7. doi: 10.31083/j.fbs1401007.

DOI:10.31083/j.fbs1401007
PMID:35320918
Abstract

Cardiac magnetic resonance has become a reliable imaging modality providing structural and functional data, and fundamental information about tissue composition. Cardiac magnetic resonance imaging with late gadolinium enhancement, T1-mapping, T2-mapping, T2*-imaging, and extracellular volume, has proved to be a valuable tool in investigating the etiology of heart failure. Such analysis is helpful for the diagnostic evaluation of both ischemic and non-ischemic cardiomyopathies. As primary heart muscle diseases, the ability to characterize the myocardial substrate is essential. Determining the heart failure etiology is fundamental and has implications regarding the prognosis prediction and best treatment. Investigation in cardiac magnetic resonance in heart failure patients has grown in the past decade, and the true value of this imaging modality to detect early disease likely remains underestimated. This review describes the importance of cardiac magnetic resonance for the diagnosis and prognosis of non-ischemic cardiomyopathies, particularly hypertrophic, infiltrative, and arrhythmogenic cardiomyopathies.

摘要

心脏磁共振成像已成为一种可靠的成像方式,可提供结构和功能数据以及有关组织成分的基本信息。采用钆延迟增强、T1映射、T2映射、T2*成像和细胞外容积的心脏磁共振成像,已被证明是研究心力衰竭病因的一种有价值的工具。这种分析有助于对缺血性和非缺血性心肌病进行诊断评估。作为原发性心肌疾病,表征心肌基质的能力至关重要。确定心力衰竭病因是根本所在,对预后预测和最佳治疗具有重要意义。在过去十年中,针对心力衰竭患者的心脏磁共振研究有所增加,而这种成像方式在检测早期疾病方面的真正价值可能仍被低估。本综述描述了心脏磁共振成像对于非缺血性心肌病,尤其是肥厚型、浸润型和致心律失常型心肌病的诊断和预后的重要性。

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Novel Genes Involved in Hypertrophic Cardiomyopathy: Data of Transcriptome and Methylome Profiling.参与肥厚型心肌病的新基因:转录组和甲基化组分析数据
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