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可可豆荚果皮(L.)新型生发乳膏配方。

New Hair Growth Cream Formulation with Cocoa Pod Peel ( L.).

机构信息

Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia.

Pharmacology and Clinical Pharmacy Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia.

出版信息

ScientificWorldJournal. 2022 Mar 14;2022:2299725. doi: 10.1155/2022/2299725. eCollection 2022.

Abstract

Our previous study verified that the waste skin of cocoa ( L) fruit or waste cocoa pod husks had the efficacy to overcome hair loss or alopecia. This study aims to determine the formula and activity of hair cream of cocoa pod peel water fraction, which is effective in stimulating hair growth. Activity testing uses the modified Tanaka method. The results showed that the cocoa husk wastewater fraction could be formulated into hair cream, but there were changes in viscosity and pH after the freeze-thaw test, but still within the allowed limit. The hair cream water fraction gel stimulated hair growth activity based on the hair length data with a significant difference in concentration of the preparation. The best activity in hair cream preparation was at 12.5% concentration. In addition, there were no signs of irritation to the rabbit's skin where hair cream preparation was applied. The results of this study indicated that cocoa fruit peel cream can be used for antialopecia treatments.

摘要

我们之前的研究已经证实,可可(L)果的废皮或废可可荚壳具有防止脱发或秃头的功效。本研究旨在确定可可荚果皮水提物配方及其促进头发生长的活性,该水提物对头发生长有显著的促进作用。活性测试采用改良的 Tanaka 法。结果表明,可可果皮废水部分可制成发乳,但经冻融试验后黏度和 pH 值发生变化,但仍在允许范围内。基于头发长度数据,发乳水提物凝胶对头发生长活性有显著差异。发乳制剂的最佳活性浓度为 12.5%。此外,发乳制剂涂抹于兔子皮肤上无刺激性迹象。本研究结果表明,可可果皮霜可用于防脱发治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb33/8938051/d314f4cca8c5/TSWJ2022-2299725.001.jpg

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