Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
An Bras Dermatol. 2022 May-Jun;97(3):399-400. doi: 10.1016/j.abd.2020.08.038. Epub 2022 Mar 20.
A 34-year-old female was referred to our department, complaining of multiple asymptomatic lesions that appeared two weeks previously. The patient had active nephritis with nephrotic syndrome and was treated with immunosuppressive therapies. Physical examination revealed multiple well-circumscribed rounds of flat brownish plaques with slightly elevated borders, some of which were covered by scales. The number of lesions was nine in total. Skin biopsy specimens showed dyskeratotic cells in the thinned epidermis with cornoid lamella, and the absence of a granular cell layer. The development of porokeratosis was considered to be related to immunosuppressive therapy or the activity of nephritis.
一位 34 岁女性因两周前出现多个无症状皮损而被转至我科。患者患有伴有肾病综合征的活动性肾炎，并接受了免疫抑制治疗。体格检查显示多个边界稍隆起、形态规则的圆形棕色扁平斑块，部分斑块覆盖鳞屑。皮损总计 9 个。皮肤活检标本显示变薄的表皮内有角化不良细胞和角层下脓疱，颗粒层缺失。考虑到患者正在接受免疫抑制治疗或肾炎活动，故认为其发生掌跖角化病与此相关。
