Raychaudhuri S P, Smoller B R
Department of Dermatology and Pathology, Stanford University School of Medicine, California.
Int J Dermatol. 1992 Nov;31(11):781-2. doi: 10.1111/j.1365-4362.1992.tb04242.x.
Porokeratosis is an uncommon, inherited, autosomally dominant disorder. In the last decade association of porokeratosis and immunosuppression has been observed. In this study we carried out a comparative study between immunosuppressed and nonimmunosuppressed porokeratosis cases. We found that 9 out of 20 cases of porokeratosis were associated with organ transplantation/immunosuppression. Clinicopathologic study revealed that the pattern of disease is alike both in immunosuppressed and nonimmunosuppressed patients. Our observations indicate that immune modulation could be a factor in the genesis of porokeratosis.
汗孔角化症是一种罕见的、遗传性的常染色体显性疾病。在过去十年中，已观察到汗孔角化症与免疫抑制之间存在关联。在本研究中，我们对免疫抑制和未免疫抑制的汗孔角化症病例进行了一项对比研究。我们发现，20例汗孔角化症病例中有9例与器官移植/免疫抑制有关。临床病理研究表明，免疫抑制和未免疫抑制患者的疾病模式相似。我们的观察结果表明，免疫调节可能是汗孔角化症发病的一个因素。
