National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK
Centre for Population Health and Interdisciplinary Research, HealthMATE 360, Ondo, Nigeria.
BMJ Open. 2022 Mar 23;12(3):e058293. doi: 10.1136/bmjopen-2021-058293.
Stillbirths and neonatal deaths are leading contributors to the global burden of disease and pregnancy ultrasound has the potential to help decrease this burden. In the absence of high-Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence on universal obstetric ultrasound screening at or close to term, many different screening strategies have been proposed. Systematic reviews have rapidly increased over the past decade owing to the diverse nature of ultrasound parameters and the wide range of possible adverse perinatal outcomes. This systematic review will summarise the evidence on key ultrasound parameters in the published literature to help develop an obstetric ultrasound protocol that identifies pregnancies at risk of adverse perinatal outcomes at or close to term.
This study will follow the recent Cochrane guidelines for a systematic review of systematic reviews. A comprehensive literature search will be conducted using Embase (OvidSP), Medline (OvidSP), CDSR, CINAHL (EBSCOhost) and Scopus. Systematic reviews evaluating at least one ultrasound parameter in late pregnancy to detect pregnancies at risk of adverse perinatal outcomes will be included. Two independent reviewers will screen, assess the quality including the risk of bias using the ROBIS tool, and extract data from eligible systematic reviews that meet the study inclusion criteria. Overlapping data will be assessed and managed with decision rules, and study evidence including the GRADE assessment of the certainty of results will be presented as a narrative synthesis as described in the Cochrane guidelines for an overview of reviews.
This research uses publicly available published data; thus, an ethics committee review is not required. The findings will be published in a peer-reviewed journal.
CRD42021266108.
死产和新生儿死亡是导致疾病全球负担的主要因素，而孕期超声检查有可能有助于降低这一负担。由于缺乏关于接近足月时进行普遍产科超声筛查的高等级推荐评估、制定和评估（GRADE）证据，因此提出了许多不同的筛查策略。由于超声参数的多样性和可能的不良围产儿结局范围广泛，过去十年中系统评价的数量迅速增加。本系统评价将总结已发表文献中关键超声参数的证据，以帮助制定产科超声方案，在接近足月时识别有不良围产儿结局风险的妊娠。
本研究将遵循最近 Cochrane 系统评价系统评价指南。将使用 Embase（OvidSP）、Medline（OvidSP）、CDSR、CINAHL（EBSCOhost）和 Scopus 进行全面文献检索。将纳入评估至少一种晚期妊娠超声参数以检测有不良围产儿结局风险的妊娠的系统评价。两名独立评审员将筛选、评估质量，包括使用 ROBIS 工具评估偏倚风险，并从符合研究纳入标准的合格系统评价中提取数据。将评估和管理重叠数据，并按照 Cochrane 指南描述的综述概述呈现研究证据，包括结果确定性的 GRADE 评估。
本研究使用了公开可用的已发表数据，因此不需要伦理委员会审查。研究结果将发表在同行评议的期刊上。
PROSPERO 注册号：CRD42021266108。
