Lumsden M A, Baird D T
Prostaglandins. 1986 Jun;31(6):1011-22. doi: 10.1016/0090-6980(86)90205-4.
Prostacyclin was infused into the uterus of non-pregnant women either during early menstruation or in the secretory phase of the cycle. A dose of 5 micrograms/min produced little systemic effect and caused a significant decrease in uterine activity on Days 1 and 2 of the menses whereas 0.5 microgram/min did not. However, when dysmenorrhoeic pain and increased uterine activity were produced by infusion of PGF2 alpha during the secretory phase, PGI2 neither decreased the activity nor the pain. This indicates that PGI2 does not cause uterine relaxation by blocking the action of PGF2 alpha.
在非孕期女性月经早期或月经周期的分泌期，将前列环素注入子宫。每分钟5微克的剂量几乎没有全身效应，在月经第1天和第2天可使子宫活动显著降低，而每分钟0.5微克的剂量则无此作用。然而，在分泌期通过注入前列腺素F2α引起痛经和子宫活动增强时，前列环素既未降低子宫活动，也未减轻疼痛。这表明前列环素不会通过阻断前列腺素F2α的作用来引起子宫松弛。
