Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1142, New Zealand.
National Institute of Water & Atmospheric Research (NIWA), P.O. Box 893, Nelson 7010, New Zealand.
J Nat Prod. 2021 Feb 26;84(2):544-547. doi: 10.1021/acs.jnatprod.0c01248. Epub 2021 Jan 26.
LCMS analysis of an extract of the New Zealand tunicate showed evidence for numerous new rubrolides. Following a mass spectrometry-guided isolation procedure, new hydrated rubrolides V and W ( and ), along with previously reported rubrolide G (), were isolated and characterized using MS and NMR. The anti-bacterial and cell cytotoxic activity of the compounds were compared to the potent anti-MRSA compound rubrolide A; hydration across the C-5/C-6 bond was shown to abrogate antibacterial activity.
LCMS 分析新西兰被囊动物的提取物显示出大量新的rubrolide。采用质谱引导的分离程序，分离并鉴定了新的水合rubrolide V 和 W（和），以及先前报道的 rubrolide G（）。化合物的抗细菌和细胞毒性活性与强效抗耐甲氧西林金黄色葡萄球菌化合物 rubrolide A 进行了比较；C-5/C-6 键上的水合作用被证明会消除抗菌活性。
