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α-胰蛋白酶抑制剂重链4在……的发育和繁殖中起重要作用。 （原文中“the Development and Reproduction of.”后面缺少具体内容）

Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 Plays an Important Role in the Development and Reproduction of .

作者信息

Ji Jin-Liang, Han Shan-Jie, Zhang Rui-Juan, Yu Jian-Bin, Li Ya-Bin, Yu Xiao-Ping, Liu Guang-Fu, Xu Yi-Peng

机构信息

Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, China Jiliang University, Hangzhou 310018, China.

出版信息

Insects. 2022 Mar 18;13(3):303. doi: 10.3390/insects13030303.

DOI:10.3390/insects13030303
PMID:35323600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8951764/
Abstract

The brown planthopper, , is a difficult-to-control insect pest affecting rice yields in Asia. As a structural component of the inter-alpha-trypsin inhibitor (ITI), the inter-alpha-trypsin inhibitor heavy chain (ITIH) has been reported to be involved in various inflammatory or malignant disorders, ovarian development, and ovulation. To reveal the function of ITIH4 in , the gene encoding ITIH4 () was cloned and characterized. ITIH4 contains a signal peptide, a vault protein inter-alpha-trypsin domain, and a von Willebrand factor type A domain. qPCR analysis showed that was expressed at all developmental stages and in all tissues (fat body, ovary, and gut), with the highest expression in the fat body. Double stranded (ds) injection clearly led to an RNAi-mediated inhibition of the expression of and resulted in reduced survival, delayed ovarian development, and reduced egg production and egg hatching. These results indicate that plays an important role in the development and reproduction of .

摘要

褐飞虱是一种难以控制的害虫，影响亚洲的水稻产量。作为α-胰蛋白酶抑制剂（ITI）的结构成分，α-胰蛋白酶抑制剂重链（ITIH）已被报道参与各种炎症或恶性疾病、卵巢发育和排卵。为了揭示ITIH4在褐飞虱中的功能，克隆并鉴定了编码ITIH4的基因（ITIH4）。ITIH4包含一个信号肽、一个穹窿蛋白α-胰蛋白酶结构域和一个血管性血友病因子A结构域。qPCR分析表明，ITIH4在所有发育阶段和所有组织（脂肪体、卵巢和肠道）中均有表达，在脂肪体中的表达最高。双链RNA（ds）注射明显导致RNAi介导的ITIH4表达抑制，并导致存活率降低、卵巢发育延迟以及产卵量和卵孵化率降低。这些结果表明，ITIH4在褐飞虱的发育和繁殖中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/265f40493573/insects-13-00303-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/0cc81bf1dd6d/insects-13-00303-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/335b041275b5/insects-13-00303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/7fd1696da9cb/insects-13-00303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/d53706b800ed/insects-13-00303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/31c370a9e43d/insects-13-00303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/265f40493573/insects-13-00303-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/0cc81bf1dd6d/insects-13-00303-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/335b041275b5/insects-13-00303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/7fd1696da9cb/insects-13-00303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/d53706b800ed/insects-13-00303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/31c370a9e43d/insects-13-00303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8919/8951764/265f40493573/insects-13-00303-g006.jpg

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