Elkattawy Hany A, Ghoneim Fatma M, Eladl Mohamed Ahmed, Said Eman, Ebrahim Hasnaa Ali, El-Shafey Mohamed, Asseri Saad Mohamed, El-Sherbiny Mohamed, Alsalamah Reem Hamoud, Elsherbiny Nehal M, Hadhod Shimaa
Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia.
Medical Physiology Department, College of Medicine, Zagazig University, Zagazig 44519, Egypt.
Antioxidants (Basel). 2022 Mar 8;11(3):514. doi: 10.3390/antiox11030514.
Aging is a naturally occurring process inevitably affecting each living human. The brain is adversely affected by aging with increased risks of developing various neurological disorders. Thus, it is essential to investigate practical approaches that can counteract the impact of aging on the brain. Vitamin K2 (Vit. K2) is a naturally occurring vitamin with reported valuable therapeutic effects. The current study highlights the role of Vit. K2 administration in counteracting age-related changes in the brain using naturally aging rats. Three-month-old rats were assigned to two groups: an ageing control group receiving a drug vehicle and an ageing group orally gavaged with Vit. K2 (30 mg/kg, once daily 5 days per week). Treatment was continued for 17 months. Ten three-month-old rats were used as the adult control. Vit. K2 improved functional performance, reduced social anxiety, depressive-like behavior, and enhanced memory performance with concomitant preservation of hippocampal and cerebral cortex tyrosine hydroxylase expression. Biochemically, Vit. K2 administration restored oxidative-anti-oxidative homeostasis in the brain. Vit. K2 modulated inflammatory signaling, as evidenced by suppression in the brain of NLRP3, caspase-1, Il-1β, TNFα, IL-6, and CD68 expression. Concomitantly, histopathological examination revealed consistent hippocampal and cerebral cortex improvement. Thus, it can be inferred that Vit K2 can slow down age-related changes in the brain associated with modulation of NLRP3/caspase-1/Nrf-2 signaling.
衰老 是一个自然发生的过程，不可避免地会影响每一个活着的人。大脑会受到衰老的不利影响，患各种神经系统疾病的风险增加。因此，研究能够抵消衰老对大脑影响的实用方法至关重要。维生素K2（Vit.K2）是一种天然存在的维生素，据报道具有宝贵的治疗作用。本研究强调了Vit.K2给药在使用自然衰老大鼠对抗大脑中与年龄相关变化方面的作用。将三个月大的大鼠分为两组：一组为衰老对照组，接受药物载体；另一组为衰老组，口服Vit.K2（30mg/kg，每周5天，每天一次）。治疗持续17个月。十只三个月大的大鼠用作成年对照。Vit.K2改善了功能表现，减轻了社交焦虑、抑郁样行为，并增强了记忆表现，同时保留了海马体和大脑皮层酪氨酸羟化酶的表达。从生化角度来看，Vit.K2给药恢复了大脑中的氧化-抗氧化稳态。Vit.K2调节炎症信号，大脑中NLRP3、caspase-1、Il-1β、TNFα、IL-6和CD68表达的抑制证明了这一点。同时，组织病理学检查显示海马体和大脑皮层持续改善。因此，可以推断Vit K2可以减缓与NLRP3/caspase-1/Nrf-2信号调节相关的大脑中与年龄相关的变化。
