Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, the Netherlands.
Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, the Netherlands; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Pharmacol Ther. 2021 Nov;227:107893. doi: 10.1016/j.pharmthera.2021.107893. Epub 2021 May 13.
The control of inflammation is strictly regulated to ensure the adequate intensity and duration of an inflammatory response, enabling the removal of the trigger factors and the restoration of the integrity of the tissues and their functions. This process is coordinated by anti-inflammatory and pro-resolving mediators that regulate the cellular and molecular events necessary to restore homeostasis, and defects in this control are associated with the development of chronic and autoimmune diseases. The TAM family of receptor tyrosine kinases-Tyro3, Axl, and MerTK-plays an essential role in efferocytosis, a key process for the resolution of inflammation. However, new studies have demonstrated that TAM receptor activation not only reduces the synthesis of pro-inflammatory mediators by different cell types in response to some stimuli but also stimulates the production of anti-inflammatory and pro-resolving molecules that control the inflammation. This review provides a comprehensive view of TAM receptor family members as important players in controlling inflammatory responses through anti-inflammatory and pro-resolving actions.
炎症的控制受到严格调节，以确保炎症反应的适当强度和持续时间，从而能够消除触发因素并恢复组织及其功能的完整性。这一过程由抗炎和促解决介质协调，这些介质调节恢复体内平衡所需的细胞和分子事件，而这种控制的缺陷与慢性和自身免疫性疾病的发展有关。受体酪氨酸激酶家族的 TAM 家族-Tyro3、Axl 和 MerTK-在细胞吞噬作用中发挥着重要作用，细胞吞噬作用是炎症消退的关键过程。然而，新的研究表明，TAM 受体的激活不仅降低了不同细胞类型对某些刺激的促炎介质的合成，还刺激了抗炎和促解决分子的产生，从而控制炎症。这篇综述全面介绍了 TAM 受体家族成员作为通过抗炎和促解决作用控制炎症反应的重要参与者。
