Service of Ophthalmology, Instituto de Investigación Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
NeurObesity Group, Department of Physiology, CIMUS, Instituto de Investigación Sanitaria, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
Cells. 2022 Mar 16;11(6):1012. doi: 10.3390/cells11061012.
We describe a case of Vogt-Koyanagi-Harada (VKH) disease exacerbation after COVID-19 vaccination. A 46-year-old woman presented with a bilateral granulomatous uveitis 2 days after the first dose of COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech), and was diagnosed with a complete Vogt-Koyanagi-Harada (VKH) disease 4 days after receiving the second dose of the vaccine. Three weeks before the first dose, she had been consulted for blurred vision and mild headaches. The case resolved with high dose intravenous corticosteroids, followed by oral prednisone. The close temporal relationship between the COVID-19 vaccine doses and the worsening of VKH symptoms strongly suggests COVID-19 vaccination as the trigger of its exacerbation.
我们描述了一例 COVID-19 疫苗接种后 Vogt-Koyanagi-Harada(VKH)病恶化的病例。一位 46 岁女性在接种第一剂 COVID-19 mRNA 疫苗(辉瑞-生物科技公司的 Comirnaty)后 2 天出现双侧肉芽肿性葡萄膜炎,并在接种第二剂疫苗后 4 天被诊断为完全 Vogt-Koyanagi-Harada(VKH)病。在第一剂疫苗前 3 周,她曾因视力模糊和轻度头痛就诊。该病例经大剂量静脉注射皮质类固醇和随后口服泼尼松治疗后得到缓解。COVID-19 疫苗接种剂量与 VKH 症状恶化之间的密切时间关系强烈提示 COVID-19 疫苗接种是其恶化的触发因素。