Department of Pathophysiology, Medical College, Nanchang University, 461 Bayi Road, Nanchang 330006, China.
Second Clinical Medical College, Nanchang University, Nanchang 330006, China.
Int J Mol Sci. 2022 Mar 8;23(6):2927. doi: 10.3390/ijms23062927.
Breast cancer (BC) is one of the most devastating cancers, with high morbidity and mortality, among the female population worldwide. In BC, mesenchymal stem cells (MSCs), as pluripotent stromal stem cells, play a significant role in TME formation and tumor progression. Recently, an increasing number of studies have demonstrated that extracellular vesicles (EVs) are essential for the crosstalk between MSCs and BC cells. MSC-derived EVs (MSC-EVs) can deliver a diversity of molecules, including lipids, proteins, and nucleic acids, etc., to target cells, and produce corresponding effects. Studies have demonstrated that MSC-EVs exert both inhibitory and promotive effects in different situations and different stages of BC. Meanwhile, MSC-EVs provide novel therapeutic options for BC, such as EVs as carriers for drug delivery. Therefore, in this review, we summarize the role of MSC-EVs in BC progression and application in clinical treatment, in the hope of providing a basis for further research.
乳腺癌（BC）是全球女性中发病率和死亡率最高的最具破坏性的癌症之一。在 BC 中，间充质干细胞（MSCs）作为多能基质干细胞，在 TME 形成和肿瘤进展中发挥重要作用。最近，越来越多的研究表明，细胞外囊泡（EVs）是 MSCs 和 BC 细胞之间串扰的关键。MSC 来源的 EVs（MSC-EVs）可以将多种分子（包括脂质、蛋白质和核酸等）递送到靶细胞，并产生相应的效应。研究表明，MSC-EVs 在不同情况下和 BC 的不同阶段发挥抑制和促进作用。同时，MSC-EVs 为 BC 提供了新的治疗选择，例如 EVs 作为药物递送的载体。因此，在这篇综述中，我们总结了 MSC-EVs 在 BC 进展中的作用及其在临床治疗中的应用，希望为进一步的研究提供依据。
